Wilpizeski C R, Lowry L D, Green S J, Smith B D, Melnick H
Department of Otolaryngology, Thomas Jefferson University Medical College, Philadelphia, PA 19107.
Otolaryngol Head Neck Surg. 1987 Nov;97(5):433-40. doi: 10.1177/019459988709700501.
It has been suggested by numerous researchers that the development of conditioned food aversion (CFA) in experimental animals represents the presence of a subjective state of illness. Squirrel monkeys with proven susceptibility to rotation-induced vomiting were given surgical bilateral labyrinthectomies, a procedure known to abolish signs and symptoms of motion sickness in human beings. Postoperatively, labyrinthectomized monkeys neither vomited nor revealed any reduction in food consumption when exposed to provocative rotation. Other samples of monkeys known to be refractory to horizontal rotation and to sinusoidal vertical motion also exhibited little tendency to acquire a conditioned aversion to banana. But monkeys who had sham operations and those who revealed weak-to-strong signs of motion sickness exhibited a marked CFA (significant reduction in food intake). The strength of CFA was much greater when elicited in the test vehicle when compared with response in the home cage. The findings are interpreted as support for a limited application of CFA procedures for inferring the presence of motion-induced nausea and malaise.
许多研究人员认为，实验动物中条件性食物厌恶（CFA）的形成代表了一种主观的疾病状态。对已证实易因旋转诱发呕吐的松鼠猴进行双侧迷路切除术，该手术已知可消除人类晕动病的体征和症状。术后，接受迷路切除术的猴子在受到诱发旋转时既不呕吐，食物摄入量也没有减少。其他已知对水平旋转和正弦垂直运动无反应的猴子样本，也几乎没有表现出对香蕉产生条件性厌恶的倾向。但是接受假手术的猴子以及表现出从轻度到重度晕动病症状的猴子则表现出明显的条件性食物厌恶（食物摄入量显著减少）。与在饲养笼中的反应相比，在测试环境中诱发的条件性食物厌恶的强度要大得多。这些发现被解释为支持有限地应用条件性食物厌恶程序来推断运动诱发的恶心和不适的存在。
