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巨核细胞分化和血小板生成过程中的脂质重塑

Lipid remodeling in megakaryocyte differentiation and platelet biogenesis.

作者信息

Jain Kanika, Tyagi Tarun, Hwa John

机构信息

Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.

Yale Cooperative Center of Excellence in Hematology, Yale University School of Medicine, New Haven, CT, USA.

出版信息

Nat Cardiovasc Res. 2023 Sep;2(9):803-804. doi: 10.1038/s44161-023-00324-9. Epub 2023 Sep 4.

DOI:10.1038/s44161-023-00324-9
PMID:37736249
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10512809/
Abstract

Lipid remodeling, from fatty acid transport and de novo lipid synthesis, is necessary for megakaryocyte differentiation and platelet production. Dietary saturated fatty acids, impaired fatty acid transport and/or dysfunction in lipid biogenesis can contribute to low platelet counts.

摘要

脂质重塑,从脂肪酸转运到从头合成脂质,对于巨核细胞分化和血小板生成是必需的。膳食饱和脂肪酸、脂肪酸转运受损和/或脂质生物合成功能障碍可导致血小板计数降低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/779d/10512809/2408902971a3/nihms-1930770-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/779d/10512809/2408902971a3/nihms-1930770-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/779d/10512809/2408902971a3/nihms-1930770-f0001.jpg

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本文引用的文献

1
Efficient megakaryopoiesis and platelet production require phospholipid remodeling and PUFA uptake through CD36.有效的巨核细胞生成和血小板生成需要通过 CD36 进行磷脂重塑和多不饱和脂肪酸摄取。
Nat Cardiovasc Res. 2023 Aug;2(8):746-763. doi: 10.1038/s44161-023-00305-y. Epub 2023 Jul 17.
2
Single-cell lipidomics reveals the organizing principle of cell fate decision.单细胞脂质组学揭示细胞命运决定的组织原则。
Nat Rev Mol Cell Biol. 2023 Jun;24(6):377. doi: 10.1038/s41580-023-00595-x.
3
What can we learn from the platelet lipidome?我们能从血小板脂质组学中学到什么?
Platelets. 2023 Dec;34(1):2182180. doi: 10.1080/09537104.2023.2182180.
4
Platelet-derived TLT-1 promotes tumor progression by suppressing CD8+ T cells.血小板衍生的 TLT-1 通过抑制 CD8+T 细胞促进肿瘤进展。
J Exp Med. 2023 Jan 2;220(1). doi: 10.1084/jem.20212218. Epub 2022 Oct 28.
5
Unfolded Protein Response Differentially Modulates the Platelet Phenotype.未折叠蛋白反应差异调节血小板表型。
Circ Res. 2022 Aug 5;131(4):290-307. doi: 10.1161/CIRCRESAHA.121.320530. Epub 2022 Jul 18.
6
CD36, a signaling receptor and fatty acid transporter that regulates immune cell metabolism and fate.CD36,一种信号受体和脂肪酸转运蛋白,调节免疫细胞代谢和命运。
J Exp Med. 2022 Jun 6;219(6). doi: 10.1084/jem.20211314. Epub 2022 Apr 19.
7
Sphingolipids control dermal fibroblast heterogeneity.鞘脂类控制皮肤成纤维细胞的异质性。
Science. 2022 Apr 15;376(6590):eabh1623. doi: 10.1126/science.abh1623.
8
De novo lipogenesis is essential for platelet production in humans.从头合成脂肪是人类血小板生成所必需的。
Nat Metab. 2020 Oct;2(10):1163-1178. doi: 10.1038/s42255-020-00272-9. Epub 2020 Sep 14.
9
Adipocyte Fatty Acid Transfer Supports Megakaryocyte Maturation.脂肪细胞脂肪酸转移支持巨核细胞成熟。
Cell Rep. 2020 Jul 7;32(1):107875. doi: 10.1016/j.celrep.2020.107875.
10
Patrolling the vascular borders: platelets in immunity to infection and cancer.巡逻血管边界:血小板在抗感染和抗癌中的作用。
Nat Rev Immunol. 2019 Dec;19(12):747-760. doi: 10.1038/s41577-019-0202-z. Epub 2019 Aug 13.