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以大面积卒中为表现的儿童抗磷脂综合征:一例报告

Pediatric Antiphospholipid Syndrome Presenting as a Massive Stroke: A Case Report.

作者信息

Marzooq Fatima A

机构信息

Radiology, Salmaniya Medical Complex, Manama, BHR.

出版信息

Cureus. 2023 Aug 21;15(8):e43834. doi: 10.7759/cureus.43834. eCollection 2023 Aug.

DOI:10.7759/cureus.43834
PMID:37736449
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10511209/
Abstract

Pediatric strokes are infrequent yet impactful occurrences with distinct challenges due to their unique pathophysiology and diagnostic complexities. Antiphospholipid syndrome, an autoimmune disorder characterized by antiphospholipid antibodies, can lead to prothrombotic states causing vascular occlusions. Here, we present the case of a previously healthy two-year-old girl who presented with sudden right-sided hemiparesis and altered consciousness. Comprehensive assessments and evaluations revealed a diagnosis of a massive left middle cerebral artery ischemic stroke secondary to antiphospholipid syndrome. The patient received intensive care, antiplatelet therapy, and supportive measures. Gradual improvement in neurological status and motor skills was observed during hospitalization, and the patient underwent comprehensive rehabilitation. This case emphasizes the importance of vigilance, thorough diagnostic evaluation, and tailored treatment strategies. Anticoagulation therapy plays a pivotal role, necessitating a delicate balance between thrombosis prevention and bleeding risk. The significance of multidisciplinary approaches and specialized care for pediatric stroke cases is underscored.

摘要

小儿中风虽不常见,但因其独特的病理生理学和诊断复杂性而具有显著挑战性且影响重大。抗磷脂综合征是一种以抗磷脂抗体为特征的自身免疫性疾病,可导致血栓前状态,引起血管闭塞。在此,我们报告一例既往健康的两岁女童病例,该女童出现突发右侧偏瘫和意识改变。全面的评估和检查显示诊断为继发于抗磷脂综合征的大面积左侧大脑中动脉缺血性中风。患者接受了重症监护、抗血小板治疗及支持措施。住院期间观察到神经状态和运动技能逐渐改善,患者接受了全面康复治疗。该病例强调了警惕性、全面诊断评估及个性化治疗策略的重要性。抗凝治疗起着关键作用,需要在预防血栓形成和出血风险之间达成微妙平衡。强调了多学科方法及小儿中风病例专科护理的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8856/10511209/69cc03c6cb0a/cureus-0015-00000043834-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8856/10511209/69cc03c6cb0a/cureus-0015-00000043834-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8856/10511209/69cc03c6cb0a/cureus-0015-00000043834-i01.jpg

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本文引用的文献

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Neuromotor Rehabilitation Interventions After Pediatric Stroke: A Focused Review.小儿卒中后的神经运动康复干预:一项聚焦综述
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Pediatric Stroke: Overview and Recent Updates.小儿卒中:概述与最新进展
Aging Dis. 2021 Jul 1;12(4):1043-1055. doi: 10.14336/AD.2021.0219. eCollection 2021 Jul.
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