Gupta Nihit, Gupta Mayank
Psychiatry, Dayton Children's Hospital, Dayton, USA.
Psychiatry and Behavioral Sciences, Southwood Psychiatric Hospital, Pittsburgh, USA.
Cureus. 2023 Aug 21;15(8):e43867. doi: 10.7759/cureus.43867. eCollection 2023 Aug.
Over the years, there have been numerous studies linking acne to depression and suicidal thoughts. Although the exact relationship between the two is still unclear, the stigma associated with acne can have a significant impact on an individual's mental health. The critical appraisal of empirical evidence reveals a lack of understanding of the relationship between acne and suicide. Several studies have demonstrated an association between acne and suicide without causal links. Thus, it is clinically important to review the risks associated with isotretinoin and obtain informed consent regarding potential harm. The use of isotretinoin should be limited to cases of severe acne. There have been reports of an increased risk of suicide six months after the completion of isotretinoin treatment, so it is recommended that follow-up monitoring continue for up to one year following the completion of the treatment.
多年来，有大量研究将痤疮与抑郁及自杀念头联系起来。尽管二者的确切关系仍不明确，但与痤疮相关的污名可能对个人心理健康产生重大影响。对实证证据的批判性评估表明，人们对痤疮与自杀之间的关系缺乏了解。多项研究已证明痤疮与自杀之间存在关联，但并无因果联系。因此，临床上审查异维A酸相关风险并就潜在危害获取知情同意非常重要。异维A酸的使用应仅限于重度痤疮病例。有报道称，异维A酸治疗结束六个月后自杀风险增加，因此建议在治疗结束后持续进行长达一年的随访监测。
