Cha So Jin, Kim Seon Sook, Shin Jin Hak, Seo Su Ryeon
Department of Molecular Bioscience, College of Biomedical Science, Kangwon National University, Chuncheon 24341, Republic of Korea.
Institute of Life Science, Kangwon National University, Chuncheon 24341, Republic of Korea.
Antioxidants (Basel). 2024 Jan 22;13(1):131. doi: 10.3390/antiox13010131.
Peiminine is the main natural alkaloid compound extracted from the Chinese herb Fritillaria. Although peiminine is known for its antioxidant and anti-inflammatory effects in conditions such as mastitis and arthritis, its impact on inflammation induced by () has not been explored. The aim of this study was to investigate the effect of peiminine on -induced inflammatory responses in the skin and to identify the underlying mechanism involved. We discovered that peiminine inhibits the -induced expression of inflammatory mediators such as pro-interleukin-1β (pro-IL-1β), cyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) in mouse bone marrow-derived macrophages (BMDMs). Peiminine suppressed the activation of nuclear factor-kappa B (NF-κB) without affecting the activation of mitogen-activated protein kinase (MAPK) pathways such as JNK, ERK, and p38 MAPK. In addition, we found that peiminine suppressed inflammatory cytokine expression and ameliorated histological symptoms in -induced mouse skin. Our study is the first to provide evidence that peiminine has an inhibitory effect on acne, and it points toward the potential of incorporating peiminine into cosmetic and pharmaceutical formulations for acne treatment.
浙贝母碱是从中药材浙贝母中提取的主要天然生物碱化合物。尽管浙贝母碱在乳腺炎和关节炎等病症中因其抗氧化和抗炎作用而闻名，但其对由（）诱导的炎症的影响尚未得到研究。本研究的目的是探讨浙贝母碱对皮肤中由（）诱导的炎症反应的影响，并确定其中涉及的潜在机制。我们发现，浙贝母碱可抑制小鼠骨髓来源巨噬细胞（BMDM）中由（）诱导的炎性介质如前白细胞介素-1β（pro-IL-1β）、环氧化酶-2（COX-2）、肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6）的表达。浙贝母碱可抑制核因子-κB（NF-κB）的激活，而不影响丝裂原活化蛋白激酶（MAPK）途径如JNK、ERK和p38 MAPK的激活。此外，我们发现浙贝母碱可抑制炎性细胞因子的表达，并改善由（）诱导的小鼠皮肤的组织学症状。我们的研究首次提供了证据，证明浙贝母碱对痤疮有抑制作用，并指出了将浙贝母碱纳入用于痤疮治疗的化妆品和药物制剂的潜力。
