Glover M G, Seaber A V, Urbaniak J R
Microsurgery. 1986;7(3):124-7. doi: 10.1002/micr.1920070305.
The prognostic importance of arterial intimal tears is not certain in the long term. We have developed a model to evaluate pure intimal damage in the absence of other soft tissue injury or arterial anastomoses to study the effect of isolated traumatic arterial intimal tears. Groups of ten rats each were examined at 1, 2, 4, 8, and 48 weeks and were shown to have no incidence of thrombosis of the femoral artery following traumatic intimal tears. Histologically, there was persistence of medial disorganization and smooth muscle hypertrophy up to 48 weeks. We feel that intimal lesions alone do not predispose a rat femoral artery to thrombosis but might do so in the presence of significant soft tissue injury or an arterial anastomosis.
从长期来看，动脉内膜撕裂的预后重要性尚不确定。我们已经开发出一种模型，用于在不存在其他软组织损伤或动脉吻合的情况下评估单纯的内膜损伤，以研究孤立性创伤性动脉内膜撕裂的影响。每组十只大鼠分别在1周、2周、4周、8周和48周接受检查，结果显示创伤性内膜撕裂后股动脉无血栓形成。组织学检查发现，直至48周时仍存在中膜结构紊乱和平滑肌肥大。我们认为，单纯的内膜损伤不会使大鼠股动脉易于形成血栓，但在存在严重软组织损伤或动脉吻合的情况下可能会导致血栓形成。
