Klein Lauren J, Ayete-Nyampong John Benaiah, Williams Annette M, Harding Lori A, Oppong Samuel A, Acra Sari, DeBaun Michael R, Imdad Aamer
Department of Pediatrics, D. Brent Polk Division of Pediatric Gastroenterology, Hepatology, and Nutrition at Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN 37232, USA.
Vanderbilt Institute for Global Health, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Methods Protoc. 2023 Sep 17;6(5):88. doi: 10.3390/mps6050088.
In pregnancies complicated by sickle cell disease (SCD), the maternal-fetal dyad is at high risk for mortality and morbidity. In healthy pregnancies, maternal nutritional status is a critical factor for the healthy growth and development of the fetus. However, there are no reviews of the current research on the nutritional status of pregnant women with SCD and pregnancy outcomes. First, we aim to assess the burden of malnutrition in pregnant women with SCD. Next, we aim to systematically evaluate if pregnant women with SCD who have poor nutritional status are at increased risk for adverse birth outcomes compared to pregnant women with sickle cell disease and normal nutritional status. We will systematically search multiple electronic databases. Our exposure is pregnant women with SCD and poor nutritional status. The primary outcomes of interest include low birth weight (categorical) and birth weight z-scores (continuous). We will also evaluate maternal and perinatal outcomes as secondary outcomes. We will evaluate the risk of bias and overall certainty of evidence with Risk of Bias in Non-randomized Studies-of Interventions (ROBINS-I), and the overall evidence will be assessed using Grading of Recommendation Assessment, Development, and Evaluation (GRADE) criteria. We will pool findings with a meta-analysis if sufficient homogeneity exists among studies. Findings will be published in a peer-reviewed journal and disseminated to SCD advocacy groups. PROSPERO registration number: 429412.
在患有镰状细胞病（SCD）的妊娠中，母婴二元组面临着高死亡率和发病率的风险。在健康妊娠中，母亲的营养状况是胎儿健康生长发育的关键因素。然而，目前尚无关于SCD孕妇营养状况及妊娠结局的研究综述。首先，我们旨在评估SCD孕妇的营养不良负担。其次，我们旨在系统地评估与营养状况正常的SCD孕妇相比，营养状况不佳的SCD孕妇出现不良分娩结局的风险是否增加。我们将系统地检索多个电子数据库。我们的暴露因素是营养状况不佳的SCD孕妇。感兴趣的主要结局包括低出生体重（分类变量）和出生体重Z评分（连续变量）。我们还将评估孕产妇和围产期结局作为次要结局。我们将使用干预性非随机研究的偏倚风险（ROBINS-I）评估偏倚风险和证据的总体确定性，并将使用推荐分级评估、制定和评价（GRADE）标准评估总体证据。如果各研究之间存在足够的同质性，我们将通过荟萃分析汇总研究结果。研究结果将发表在同行评审期刊上，并分发给SCD宣传团体。PROSPERO注册号：429412。
