Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Department of Paediatric Rheumatology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Curr Rheumatol Rep. 2023 Dec;25(12):247-258. doi: 10.1007/s11926-023-01115-8. Epub 2023 Sep 22.
The resident gut microbiota serves as a double-edged sword that aids the host in multiple ways to preserve a healthy equilibrium and serve as early companions and boosters for the gradual evolution of our immune defensive layers; nevertheless, the perturbation of the symbiotic resident intestinal communities has a profound impact on autoimmunity induction, particularly in systemic lupus erythematosus (SLE). Herein, we seek to critically evaluate the microbiome research in SLE with a focus on intestinal dysbiosis.
SLE is a complex and heterogeneous disorder with self-attack due to loss of tolerance, and there is aberrant excessive immune system activation. There is mounting evidence suggesting that intestinal flora disturbances may accelerate the formation and progression of SLE, presumably through a variety of mechanisms, including intestinal barrier dysfunction and leaky gut, molecular mimicry, bystander activation, epitope spreading, gender bias, and biofilms. Gut microbiome plays a critical role in SLE pathogenesis, and additional studies are warranted to properly define the impact of gut microbiome in SLE, which can eventually lead to new and potentially safer management approaches for this debilitating disease.
常驻肠道菌群是一把双刃剑，它以多种方式帮助宿主保持健康平衡，并作为宿主免疫防御层逐渐进化的早期伙伴和促进者；然而，共生常驻肠道群落的失调对自身免疫的诱导有深远的影响，特别是在系统性红斑狼疮（SLE）中。在此，我们旨在批判性地评估 SLE 中的微生物组研究，重点关注肠道菌群失调。
SLE 是一种复杂的异质性疾病，由于自身耐受性丧失而导致自身攻击，并且存在异常的过度免疫系统激活。越来越多的证据表明，肠道菌群紊乱可能通过多种机制加速 SLE 的形成和进展，包括肠道屏障功能障碍和肠漏、分子模拟、旁观者激活、表位扩展、性别偏见和生物膜。肠道微生物组在 SLE 的发病机制中起着关键作用，需要进一步的研究来正确定义肠道微生物组在 SLE 中的影响，这最终可能为这种使人衰弱的疾病带来新的、潜在更安全的治疗方法。
