Technical University of Denmark , Kemitorvet, Denmark.
Veterinary Services Department, Ministry of Food and Agriculture, National Food Safety Laboratory , Accra, Ghana.
mSystems. 2023 Oct 26;8(5):e0062923. doi: 10.1128/msystems.00629-23. Epub 2023 Sep 22.
To the best of our knowledge, this is the first report on the resistomes that are measured using metagenomics in livestock from Sub-Saharan Africa. We find notable differences in the microbiomes between both pigs and poultry, and those also varied markedly compared to similar samples from Europe. However, for both animal species, the same bacterial taxa drove such differences. In pigs and urban free-range poultry, we find a very low abundance of antimicrobial resistance genes (ARGs), whereas rural free-range poultry displayed similarity to the European average, and industrialized poultry exhibited higher levels. These findings show how different African livestock bacterial communities and resistomes are from their European counterparts. They also underscore the importance of continued surveillance and investigation into antimicrobial resistance across diverse ecosystems, contributing significantly to global efforts toward combating the threat of antibiotic resistance.
据我们所知，这是首次利用宏基因组学方法对撒哈拉以南非洲地区家畜的抗药组进行的研究报告。我们发现，猪和家禽的微生物组之间存在显著差异，与欧洲的类似样本相比，这些差异也非常明显。然而，对于这两种动物物种，同样的细菌类群驱动了这些差异。在猪和城市自由放养家禽中，我们发现抗微生物药物耐药基因 (ARGs) 的丰度非常低，而农村自由放养家禽与欧洲平均水平相似，工业化家禽则表现出更高的水平。这些发现表明，非洲家畜的细菌群落和抗药组与欧洲的有很大不同。它们还强调了在不同生态系统中继续监测和调查抗微生物药物耐药性的重要性，这对全球对抗抗生素耐药性威胁的努力做出了重大贡献。
