UMR ASTRE, CIRAD, INRAE, University of Montpellier (I-MUSE) , Montpellier, France.
Département Médicaments et Technologies pour la Santé, Université Paris Saclay, CEA, INRAE , Bagnols-sur-Cèze, France.
J Virol. 2023 Oct 31;97(10):e0072323. doi: 10.1128/jvi.00723-23. Epub 2023 Sep 22.
(LSDV) is the causative agent of an economically important cattle disease which is notifiable to the World Organisation for Animal Health. Over the past decades, the disease has spread at an alarming rate throughout the African continent, the Middle East, Eastern Europe, the Russian Federation, and many Asian countries. While multiple LDSV whole genomes have made further genetic comparative analyses possible, knowledge on the protein composition of the LSDV particle remains lacking. This study provides for the first time a comprehensive proteomic analysis of an infectious LSDV particle, prompting new efforts toward further proteomic LSDV strain characterization. Furthermore, this first incursion within the capripoxvirus proteome represents one of very few proteomic studies beyond the sole genus, for which most of the proteomics studies have been performed. Providing new information about other chordopoxviruses may contribute to shedding new light on protein composition within the family.
(LSDV) 是一种经济上重要的牛病的病原体，这种病需要向世界动物卫生组织报告。在过去几十年中，这种疾病在非洲大陆、中东、东欧、俄罗斯联邦和许多亚洲国家以惊人的速度传播。虽然已经有多个 LSDV 全基因组可供进一步的遗传比较分析，但 LSDV 颗粒的蛋白质组成仍然知之甚少。本研究首次对感染性 LSDV 颗粒进行了全面的蛋白质组学分析，为进一步的 LSDV 株蛋白质组学特征分析提供了新的动力。此外，这是 capripoxvirus 蛋白质组中首次深入研究，超越了仅有的一个属，大多数蛋白质组学研究都是在该属内进行的。提供有关其他正痘病毒的新信息可能有助于揭示 科内的蛋白质组成。
