Program in Bioinformatics and Systems Biology, University of California San Diego, La Jolla, CA 92093, USA.
Program in Bioinformatics and Systems Biology, University of California San Diego, La Jolla, CA 92093, USA; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA.
Mol Cell. 2023 Sep 21;83(18):3234-3235. doi: 10.1016/j.molcel.2023.08.026.
A recent study by Liang et al. reveals that interacting enhancer RNAs (eRNAs) and promoter-transcribed upstream antisense RNAs (uaRNAs) can identify enhancer-promoter interactions. Complementary sequences within the interacting eRNAs and uaRNAs, predominantly Alu sequences, confer the specificity for eRNA-uaRNA pairing and hence enhancer-promoter recognition.
梁等人的一项最新研究表明,相互作用的增强子 RNA(eRNA)和启动子转录的上游反义 RNA(uaRNA)可以识别增强子-启动子相互作用。相互作用的 eRNA 和 uaRNA 内的互补序列,主要是 Alu 序列,赋予了 eRNA-uaRNA 配对的特异性,从而实现了增强子-启动子的识别。