Zhang Jianye, Sun Mingna, Elmaidomy Abeer H, Youssif Khayrya A, Zaki Adham M M, Hassan Kamal Hossam, Sayed Ahmed M, Abdelmohsen Usama Ramadan
Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, China.
Department of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62511, Egypt.
Food Funct. 2023 Oct 16;14(20):9050-9082. doi: 10.1039/d3fo01770b.
The study of all chemical processes involving metabolites is known as metabolomics. It has been developed into an essential tool in several disciplines, such as the study of plant physiology, drug development, human diseases, and nutrition. The field of food science, diagnostic biomarker research, etiological analysis in the field of medical therapy, and raw material quality, processing, and safety have all benefited from the use of metabolomics recently. Food metabolomics includes the use of metabolomics in food production, processing, and human diets. As a result of changing consumer habits and the rising of food industries all over the world, there is a remarkable increase in interest in food quality and safety. It requires the employment of various technologies for the food supply chain, processing of food, and even plant breeding. This can be achieved by understanding the metabolome of food, including its biochemistry and composition. Additionally, Food metabolomics can be used to determine the similarities and differences across crop kinds, as an indicator for tracking the process of ripening to increase crops' shelf life and attractiveness, and identifying metabolites linked to pathways responsible for postharvest disorders. Moreover, nutritional metabolomics is used to investigate the connection between diet and human health through detection of certain biomarkers. This review assessed and compiled literature on food metabolomics research with an emphasis on metabolite extraction, detection, and data processing as well as its applications to the study of food nutrition, food-based illness, and phytochemical analysis. Several studies have been published on the applications of metabolomics in food but further research concerning the use of standard reproducible procedures must be done. The results published showed promising uses in the food industry in many areas such as food production, processing, and human diets. Finally, metabolome-wide association studies (MWASs) could also be a useful predictor to detect the connection between certain diseases and low molecular weight biomarkers.
对所有涉及代谢物的化学过程的研究被称为代谢组学。它已发展成为多个学科中的一项重要工具，如植物生理学研究、药物开发、人类疾病研究和营养研究。食品科学领域、诊断生物标志物研究、医学治疗领域的病因分析以及原材料质量、加工和安全等方面最近都受益于代谢组学的应用。食品代谢组学包括代谢组学在食品生产、加工和人类饮食中的应用。由于消费者习惯的改变以及全球食品行业的兴起，人们对食品质量和安全的关注度显著提高。这就需要在食品供应链、食品加工乃至植物育种中采用各种技术。这可以通过了解食品的代谢组来实现，包括其生物化学和组成。此外，食品代谢组学可用于确定不同作物种类之间的异同，作为跟踪成熟过程以延长作物保质期和提高吸引力的指标，并识别与采后病害相关途径的代谢物。此外，营养代谢组学用于通过检测某些生物标志物来研究饮食与人类健康之间的联系。本综述评估并汇编了有关食品代谢组学研究的文献，重点关注代谢物提取、检测和数据处理及其在食品营养、食源性疾病和植物化学分析研究中的应用。关于代谢组学在食品中的应用已经发表了几项研究，但必须进一步开展关于使用标准可重复程序的研究。已发表的结果显示在食品生产、加工和人类饮食等许多领域的食品工业中具有广阔的应用前景。最后，全代谢组关联研究（MWASs）也可能是检测某些疾病与低分子量生物标志物之间联系的有用预测工具。
