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免疫功能低下患者的抗菌药物管理:现状与未来机遇

Antimicrobial Stewardship in Immunocompromised Patients: Current State and Future Opportunities.

作者信息

Hand Jonathan, Imlay Hannah

机构信息

Ochsner Health, New Orleans, LA, USA; University of Queensland School of Medicine, Ochsner Clinical School.

University of Utah Department of Internal Medicine, Salt Lake City, UT, USA.

出版信息

Infect Dis Clin North Am. 2023 Dec;37(4):823-851. doi: 10.1016/j.idc.2023.08.002. Epub 2023 Sep 21.

Abstract

Immunocompromised (IC) patients are high risk for complications due to a high rate of antibiotic exposure. Antimicrobial stewardship interventions targeted to IC patients can be challenging due to limited data in this population and a high risk of severe infection-related outcomes. Here, the authors review immunocompromised antimicrobial stewardship barriers, metrics, and opportunities for antimicrobial use and testing optimization. Last, the authors highlight future steps in the field.

摘要

免疫功能低下(IC)患者由于抗生素暴露率高,发生并发症的风险也高。由于该人群的数据有限以及严重感染相关结局的高风险,针对IC患者的抗菌药物管理干预措施可能具有挑战性。在此,作者回顾了免疫功能低下患者抗菌药物管理的障碍、指标以及抗菌药物使用和检测优化的机会。最后,作者强调了该领域未来的发展方向。

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