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Is Shorter Better in Oncology Patients, Too? A Retrospective Cohort Study of Short- Versus Long-Course Antibiotic Therapy for Uncomplicated Infections in Solid Tumor Patients Receiving Care in Ambulatory Oncology Clinics.在肿瘤患者中疗程较短也更好吗？一项针对在门诊肿瘤诊所接受治疗的实体瘤患者单纯性感染的短疗程与长疗程抗生素治疗的回顾性队列研究。
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本文引用的文献

1
Individualised, short-course antibiotic treatment versus usual long-course treatment for ventilator-associated pneumonia (REGARD-VAP): a multicentre, individually randomised, open-label, non-inferiority trial.个体化短疗程抗生素治疗与呼吸机相关性肺炎常规长疗程治疗的比较（REGARD-VAP）：一项多中心、个体随机、开放标签、非劣效性试验
Lancet Respir Med. 2024 May;12(5):399-408. doi: 10.1016/S2213-2600(23)00418-6. Epub 2024 Jan 22.
2
Is Short-Course Antibiotic Therapy Suitable for Pseudomonas aeruginosa Bloodstream Infections in Onco-hematology Patients With Febrile Neutropenia? Results of a Multi-institutional Analysis.短程抗生素治疗适合血液感染铜绿假单胞菌的血液感染血液病患者伴有发热性中性粒细胞减少症？多机构分析的结果。
Clin Infect Dis. 2024 Mar 20;78(3):518-525. doi: 10.1093/cid/ciad605.
3
Antimicrobial Stewardship in Immunocompromised Patients: Current State and Future Opportunities.免疫功能低下患者的抗菌药物管理：现状与未来机遇
Infect Dis Clin North Am. 2023 Dec;37(4):823-851. doi: 10.1016/j.idc.2023.08.002. Epub 2023 Sep 21.
4
Cancer is chronic but antimicrobial stewardship is iconic: A retrospective cohort of optimal antibiotic use in ambulatory oncology clinics.癌症是一种慢性病，但抗菌药物管理是关键：一项关于门诊肿瘤诊所最佳抗生素使用情况的回顾性队列研究。
Antimicrob Steward Healthc Epidemiol. 2023 May 2;3(1):e81. doi: 10.1017/ash.2023.152. eCollection 2023.
5
Antibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study.抗生素治疗与老年晚期癌症患者的药物不良事件有关：一项队列研究。
Palliat Med. 2023 May;37(5):793-798. doi: 10.1177/02692163231162889. Epub 2023 Mar 31.
6
2 days versus 5 days of postoperative antibiotics for complex appendicitis: a pragmatic, open-label, multicentre, non-inferiority randomised trial.复杂性阑尾炎术后使用抗生素2天与5天的比较：一项实用、开放标签、多中心、非劣效性随机试验
Lancet. 2023 Feb 4;401(10374):366-376. doi: 10.1016/S0140-6736(22)02588-0. Epub 2023 Jan 17.
7
Observational versus randomized controlled trials to inform antibiotic treatment durations: a narrative review.观察性研究与随机对照试验对确定抗生素治疗疗程的作用：一篇叙述性综述
Clin Microbiol Infect. 2023 Feb;29(2):165-170. doi: 10.1016/j.cmi.2022.09.002. Epub 2022 Sep 13.
8
Shorter antibiotic courses in the immunocompromised: the impossible dream?免疫功能低下患者使用更短疗程抗生素：这是个不可能实现的梦想吗？
Clin Microbiol Infect. 2023 Feb;29(2):143-149. doi: 10.1016/j.cmi.2022.08.007. Epub 2022 Aug 19.
9
Pharmacist-Driven Transitions of Care Practice Model for Prescribing Oral Antimicrobials at Hospital Discharge.药师主导的出院患者口服抗菌药物管理模式
JAMA Netw Open. 2022 May 2;5(5):e2211331. doi: 10.1001/jamanetworkopen.2022.11331.
10
Evaluation of antibiotic appropriateness at an outpatient oncology centre.门诊肿瘤中心抗生素使用合理性评估
J Oncol Pharm Pract. 2023 Jun;29(4):874-884. doi: 10.1177/10781552221087604. Epub 2022 Mar 21.

在肿瘤患者中疗程较短也更好吗？一项针对在门诊肿瘤诊所接受治疗的实体瘤患者单纯性感染的短疗程与长疗程抗生素治疗的回顾性队列研究。

Is Shorter Better in Oncology Patients, Too? A Retrospective Cohort Study of Short- Versus Long-Course Antibiotic Therapy for Uncomplicated Infections in Solid Tumor Patients Receiving Care in Ambulatory Oncology Clinics.

作者信息

Arena Christen J, El-Tatari Beisan, Lovric Kristen, Greenlee Sage B, Kenney Rachel M, Gadgeel Shirish M, Patterson Katelyn, Shallal Anita B, Alangaden George J, Davis Susan L, Veve Michael P

机构信息

Department of Pharmacy, Henry Ford Hospital, Detroit, Michigan, USA.

Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA.

出版信息

Open Forum Infect Dis. 2025 Aug 21;12(9):ofaf505. doi: 10.1093/ofid/ofaf505. eCollection 2025 Sep.

DOI:10.1093/ofid/ofaf505
PMID:40908971
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12405994/
Abstract

This retrospective cohort study evaluated short- versus long-course antibiotics for uncomplicated infections in ambulatory solid tumor patients. Among 303 patients, outcomes were similar between groups, including infection recurrence, treatment delays, and adverse events. Short-course therapy was not associated with worse outcomes, suggesting it may be a viable alternative.

摘要

这项回顾性队列研究评估了门诊实体瘤患者单纯性感染采用短疗程与长疗程抗生素治疗的效果。在303名患者中，两组之间的结果相似，包括感染复发、治疗延迟和不良事件。短疗程治疗与较差的结果无关，表明它可能是一种可行的替代方案。