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[局限性星形细胞胶质瘤]

[Circumscribed Astrocytic Gliomas].

作者信息

Hayashi Hiroaki, Iwashita Hiromichi, Tateishi Kensuke

机构信息

Department of Pediatrics, Yokohama City University Graduate School of Medicine.

出版信息

No Shinkei Geka. 2023 Sep;51(5):884-891. doi: 10.11477/mf.1436204830.

Abstract

In the fifth edition central nervous system tumours volume of the WHO Classification of Tumours series, gliomas, glioneuronal tumors, and neuronal tumors are divided into six groups. The term "circumscribed" is used to refer to a relatively contained growth pattern, as compared to other inherently "diffuse" tumors. Circumscribed astrocytic gliomas include six types: pilocytic astrocytoma, high-grade astrocytoma with piloid features, pleomorphic xanthoastrocytoma, subependymal giant cell astrocytoma, chordoid glioma, and astroblastoma, -altered. The vast majority of circumscribed astrocytic gliomas harbor genetic alterations in the mitogen-activated protein kinase pathway. Here, we review the circumscribed astrocytic gliomas, including etiology, clinical and imaging features, pathology and molecular genetics, treatment, and prognosis. This study will lead to better understanding of these newly classified tumors.

摘要

在世界卫生组织肿瘤分类系列的第五版中枢神经系统肿瘤卷中,胶质瘤、神经胶质神经元肿瘤和神经元肿瘤被分为六组。与其他本质上“弥漫性”肿瘤相比,术语“局限性”用于指相对局限的生长模式。局限性星形细胞胶质瘤包括六种类型:毛细胞型星形细胞瘤、具有毛细胞样特征的高级别星形细胞瘤、多形性黄色星形细胞瘤、室管膜下巨细胞星形细胞瘤、脊索样胶质瘤和成胶质细胞瘤。绝大多数局限性星形细胞胶质瘤在丝裂原活化蛋白激酶途径中存在基因改变。在此,我们综述局限性星形细胞胶质瘤,包括病因、临床和影像学特征、病理学和分子遗传学、治疗及预后。本研究将有助于更好地理解这些新分类的肿瘤。

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