School of Kinesiology, Shanghai University of Sport, Shanghai, China.
School of Physical Education, Liaoning Normal University, Dalian, Liaoning, China.
Front Immunol. 2023 Sep 6;14:1227945. doi: 10.3389/fimmu.2023.1227945. eCollection 2023.
Idiopathic inflammatory myopathies (IIMs) are common autoimmune diseases that affect skeletal muscle quality and function. The lack of an early diagnosis and treatment can lead to irreversible muscle damage. Non-coding RNAs (ncRNAs) play an important role in inflammatory transfer, muscle regeneration, differentiation, and regulation of specific antibody levels and pain in IIMs. ncRNAs can be detected in blood and hair; therefore, ncRNAs detection has great potential for diagnosing, preventing, and treating IIMs in conjunction with other methods. However, the specific roles and mechanisms underlying the regulation of IIMs and their subtypes remain unclear. Here, we review the mechanisms by which micro RNAs and long non-coding RNA-messenger RNA networks regulate IIMs to provide a basis for ncRNAs use as diagnostic tools and therapeutic targets for IIMs.
特发性炎性肌病（IIM）是常见的自身免疫性疾病，影响骨骼肌的质量和功能。缺乏早期诊断和治疗可能导致不可逆转的肌肉损伤。非编码 RNA（ncRNA）在炎症转移、肌肉再生、分化以及调节 IIM 中的特定抗体水平和疼痛方面发挥着重要作用。ncRNA 可以在血液和头发中检测到；因此，ncRNA 的检测与其他方法相结合，具有很大的潜力来诊断、预防和治疗 IIM。然而，IIM 及其亚型的具体调控机制尚不清楚。在这里，我们综述了 microRNA 和长非编码 RNA-信使 RNA 网络调控 IIM 的机制，为 ncRNA 作为 IIM 诊断工具和治疗靶点的应用提供了依据。
