Institute of Marine Sciences and Guangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University, Shantou, China.
College of Ocean Food and Biological Engineering, Fujian Provincial Key Laboratory of Food Microbiology and Enzyme Engineering, Jimei University, Xiamen, Fujian, China.
Front Immunol. 2023 Sep 7;14:1241934. doi: 10.3389/fimmu.2023.1241934. eCollection 2023.
Besides dividing the organism's immune system into adaptive and innate immunity, it has long been thought that only adaptive immunity can establish immune memory. However, many studies have shown that innate immunity can also build immunological memory through epigenetic reprogramming and modifications to resist pathogens' reinfection, known as trained immunity. This paper reviews the role of mitochondrial metabolism and epigenetic modifications and describes the molecular foundation in the trained immunity of arthropods and mollusks. Mitochondrial metabolism and epigenetic modifications complement each other and play a key role in trained immunity.
除了将生物体的免疫系统分为适应性免疫和固有免疫外，长期以来一直认为只有适应性免疫才能建立免疫记忆。然而，许多研究表明，固有免疫也可以通过表观遗传重编程和修饰来抵抗病原体的再次感染，这被称为训练免疫。本文综述了线粒体代谢和表观遗传修饰在节肢动物和软体动物训练免疫中的作用，并描述了其分子基础。线粒体代谢和表观遗传修饰相互补充，在训练免疫中起着关键作用。
