Central Laboratory of Advanced Diagnosis and Biomedical Research (CLADIBIOR), 90127 Palermo, Italy.
Department of Biomedicine, Neurosciences and Advanced Diagnostic (Bi.N.D.), University of Palermo, 90127 Palermo, Italy.
Cells. 2022 May 17;11(10):1663. doi: 10.3390/cells11101663.
Immune cells undergo different metabolic pathways or immunometabolisms to interact with various antigens. Immunometabolism links immunological and metabolic processes and is critical for innate and adaptive immunity. Although metabolic reprogramming is necessary for cell differentiation and proliferation, it may mediate the imbalance of immune homeostasis, leading to the pathogenesis and development of some diseases, such as autoimmune diseases. Here, we discuss the effects of metabolic changes in autoimmune diseases, exerted by the leading actors of innate immunity, and their role in autoimmunity pathogenesis, suggesting many immunotherapeutic approaches.
免疫细胞通过不同的代谢途径或免疫代谢来与各种抗原相互作用。免疫代谢将免疫和代谢过程联系起来，对固有和适应性免疫至关重要。虽然代谢重编程对于细胞分化和增殖是必要的，但它可能介导免疫稳态的失衡，导致某些疾病（如自身免疫性疾病）的发病和发展。在这里，我们讨论了先天免疫的主要参与者引起的自身免疫性疾病中的代谢变化的影响，以及它们在自身免疫发病机制中的作用，并提出了许多免疫治疗方法。
