Department of Rehabilitation, China-Japan Union Hospital of Jilin University, Changchun, China.
School of Nursing, Jilin University, Changchun, China.
Front Public Health. 2023 Sep 6;11:1075946. doi: 10.3389/fpubh.2023.1075946. eCollection 2023.
According to reports, maternal rheumatoid arthritis (RA) has been suggested as a possible adverse factor for developing small for gestational age (SGA) in offspring. However, some studies have also indicated a need for a more statistically significant association between the two. Understanding the relationship between maternal RA and the risk of SGA is crucial for identifying potential adverse outcomes and implementing appropriate interventions. Therefore, this study aims to elucidate the association between maternal RA and the risk of offspring developing SGA.
This study was registered on the International Prospective Register of Systematic Reviews (PROSPERO) (ID: CRD42022357590). A systematic literature search was conducted to identify eligible studies up to August 2022. Quality assessment was performed according to the Newcastle-Ottawa scale. The Q test and I test tested and estimated heterogeneity among studies. Odds ratios (ORs) with 95% CI were calculated using random or fixed effects models depending on the heterogeneity. Subgroup analyses, sensitivity analyses, and publication bias assessments were also performed.
Seven studies, including 12,323,918 participants, were included in the analysis. The results showed a statistically significant association between maternal RA and SGA (OR = 1.70, 95% CI = 1.29-2.23, < 0.001). Sensitivity analysis showed stable results. The funnel plot of the symmetric distribution and the results of Begg's and Egger's tests showed no publication bias.
Maternal RA is associated with an increased risk of SGA in offspring. However, more studies are still needed to explore the potential mechanisms underlying maternal RA and SGA association.
https://www.crd.york.ac.uk/PROSPERO/, identifier [CRD42022357590].
据报道，母体类风湿关节炎（RA）被认为是导致胎儿生长受限（SGA）的一个可能的不利因素。然而，一些研究也表明，两者之间需要有更具统计学意义的关联。了解母体 RA 与 SGA 风险之间的关系对于识别潜在的不良后果和实施适当的干预措施至关重要。因此，本研究旨在阐明母体 RA 与胎儿发生 SGA 的风险之间的关联。
本研究已在国际前瞻性系统评价注册库（PROSPERO）（注册号：CRD42022357590）注册。截至 2022 年 8 月，进行了系统的文献检索，以确定符合条件的研究。根据纽卡斯尔-渥太华量表进行质量评估。Q 检验和 I 检验用于检验和估计研究之间的异质性。使用随机或固定效应模型计算优势比（OR）及其 95%置信区间，具体取决于异质性。还进行了亚组分析、敏感性分析和发表偏倚评估。
共纳入了 7 项研究，包括 12323918 名参与者。结果显示，母体 RA 与 SGA 之间存在统计学显著关联（OR=1.70，95%CI=1.29-2.23，<0.001）。敏感性分析结果稳定。漏斗图呈对称分布，贝格和埃格检验结果显示无发表偏倚。
母体 RA 与胎儿 SGA 风险增加相关。然而，仍需要更多的研究来探索母体 RA 和 SGA 关联的潜在机制。
