法属圭亚那的儿童哮喘情况如何？一项基于在卡宴医院中心转诊至过敏科会诊的儿童的队列研究。

What's childhood asthma in French Guiana? A cohort study based on children referred for allergology consultations at the Cayenne hospital center.

作者信息

Maniassom Chiméne, Defo Antoine, De Blay Frédéric, Elenga Narcisse

机构信息

Department de Pediatrie, Hôpital de Cayenne "Andrée Rosemon", Cayenne, French Guiana.

Pôle de Pathologie Thoracique Hôpitaux Universitaires de Strasbourg, Place de l'Hôpital, Strasbourg, France.

出版信息

Front Public Health. 2023 Sep 7;11:1198937. doi: 10.3389/fpubh.2023.1198937. eCollection 2023.

DOI:10.3389/fpubh.2023.1198937

PMID:37744508

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10513413/

Abstract

BACKGROUND

Asthma is a multifactorial chronic disease, whose most frequent etiology is allergy, especially to . In French Guiana, the childhood prevalence of Blomia T sensitization is unkwown. The aim of this study was to determine the proportion of sensitization to Blomia T and other mites in asthmatic children, and to describe the characteristics of childhood asthma in French Guiana.

METHODS

A retrospective cohort study focused on children from 0 to 18 years of age, followed for asthma at the Department of Pediatrics of the Cayenne Hospital Center in French Guiana. All asthmatic children followed by the same paediatric allergist were systematically skin-tested with Bt total extract, and Bt-specific IgE tests were additionally performed to confirm specific sensitization. All follow-up variables were collected from medical records. The outcome was sensitization to and other allergens, and the explanatory variables were those of asthma follow-up. Patients were categorized into sensitization yes/no. Logistic regression analysis was used to assess the relationship between follow-up variables and the outcome.

RESULTS

302 patients were followed: 177 cases of allergic rhinitis, 135 allergic conjunctivitis, 105 atopic dermatitis, 153 food allergy, and 14 cases of drug allergy. Poly-allergy (respiratory, food, skin, and medicinal) was present in 239 children. There were 158 children followed for asthma, of whom 103 (65%) were sensitized to . The median age of the asthmatic children sensitized to was 7 years, and 3 years for those who were not sensitized ( < 0.001). Among the girls ( = 58), 67% were sensitized to ; 97 (92%) asthmatic children co-sensitized to , and . Multivariate analysis showed that the childhood asthma in French Guiana is characterized by a median age of 7 years ( < 0.001), a high prevalence of ( < 0.001), co-sensitization to other mites (p < 0.001), and a high prevalence of co-sensitization to cockroaches ( = 0.006). The area under the ROC curve was close to 0.9, confirming the quality of our model.

CONCLUSION

In French Guiana, asthma is characterized by a high prevalence of Blomia tropicalis sensitization.

摘要

背景

哮喘是一种多因素慢性疾病，其最常见的病因是过敏，尤其是对……过敏。在法属圭亚那，儿童对热带花草螨（Blomia T）致敏的患病率尚不清楚。本研究的目的是确定哮喘儿童中对热带花草螨和其他螨虫致敏的比例，并描述法属圭亚那儿童哮喘的特征。

方法

一项回顾性队列研究聚焦于0至18岁的儿童，这些儿童在法属圭亚那卡宴医院中心儿科接受哮喘随访。所有由同一位儿科过敏症专科医生随访的哮喘儿童均接受了热带花草螨（Bt）全提取物的系统性皮肤试验，并额外进行了Bt特异性IgE检测以确认特异性致敏。所有随访变量均从病历中收集。结果是对热带花草螨和其他过敏原的致敏情况，解释变量是哮喘随访的变量。患者被分为热带花草螨致敏是/否两类。采用逻辑回归分析来评估随访变量与结果之间的关系。

结果

共随访了302例患者：177例过敏性鼻炎、135例过敏性结膜炎、105例特应性皮炎、153例食物过敏和14例药物过敏。239名儿童存在多种过敏（呼吸道、食物、皮肤和药物过敏）。有158名儿童接受哮喘随访，其中103名（65%）对热带花草螨致敏。对热带花草螨致敏的哮喘儿童的中位年龄为7岁，未致敏儿童的中位年龄为3岁（P<0.001）。在女孩（n=58）中，67%对热带花草螨致敏；97名（92%）哮喘儿童对热带花草螨、粉尘螨和屋尘螨共同致敏。多因素分析显示，法属圭亚那的儿童哮喘具有以下特征：中位年龄为7岁（P<0.001）、热带花草螨致敏率高（P<0.001）、对其他螨虫共同致敏（P<0.001）以及对蟑螂共同致敏率高（P=0.006）。ROC曲线下面积接近0.9，证实了我们模型的质量。