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Prediction of Druggable Allosteric Sites of Undruggable Multidrug Resistance Efflux Pump Proteins.

作者信息

Yadalam Pradeep Kumar, Anegundi Raghavendra Vamsi, Heboyan Artak

机构信息

Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.

Department of Prosthodontics, Faculty of Stomatology, Yerevan State Medical University after Mkhitar Heratsi, Yerevan, Armenia.

出版信息

Biomed Eng Comput Biol. 2023 Sep 21;14:11795972231202394. doi: 10.1177/11795972231202394. eCollection 2023.

DOI:10.1177/11795972231202394
PMID:37745982
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10515579/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd41/10515579/a6abdbccce5d/10.1177_11795972231202394-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd41/10515579/d29de3847b88/10.1177_11795972231202394-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd41/10515579/a6abdbccce5d/10.1177_11795972231202394-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd41/10515579/d29de3847b88/10.1177_11795972231202394-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd41/10515579/a6abdbccce5d/10.1177_11795972231202394-fig2.jpg

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本文引用的文献

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PASSer: Prediction of Allosteric Sites Server.PASSer：变构位点预测服务器。
Mach Learn Sci Technol. 2021 Sep;2(3). doi: 10.1088/2632-2153/abe6d6. Epub 2021 May 13.
2
Efflux pump inhibitors for bacterial pathogens: From bench to bedside.外排泵抑制剂在细菌病原体中的应用：从实验室到临床。
Indian J Med Res. 2019 Feb;149(2):129-145. doi: 10.4103/ijmr.IJMR_2079_17.
3
Computational Tools for Allosteric Drug Discovery: Site Identification and Focus Library Design.变构药物发现的计算工具：位点识别与聚焦文库设计
Methods Mol Biol. 2017;1529:439-446. doi: 10.1007/978-1-4939-6637-0_23.
4
Disruption of allosteric response as an unprecedented mechanism of resistance to antibiotics.变构反应的破坏作为一种前所未有的抗生素耐药机制。
J Am Chem Soc. 2014 Jul 16;136(28):9814-7. doi: 10.1021/ja5030657. Epub 2014 Jul 2.
5
Role of efflux pumps in the antibiotic resistance of bacteria embedded in a biofilm.生物膜中嵌入的细菌的外排泵在抗生素耐药性中的作用。
Virulence. 2013 Apr 1;4(3):223-9. doi: 10.4161/viru.23724. Epub 2013 Feb 4.
6
Antibiotic resistance of subgingival species in chronic periodontitis patients.慢性牙周炎患者龈下物种的抗生素耐药性。
J Periodontal Res. 2010 Aug;45(4):557-63. doi: 10.1111/j.1600-0765.2010.01274.x. Epub 2010 Jun 10.
7
Nucleotide sequence of a Porphyromonas gingivalis gene encoding a surface-associated glutamate dehydrogenase and construction of a glutamate dehydrogenase-deficient isogenic mutant.
Infect Immun. 1994 Apr;62(4):1358-68. doi: 10.1128/iai.62.4.1358-1368.1994.