Wang Zhuoran, Li Nan, Cai Peng, Zhang Cunzhen, Cao Guangwen, Yin Jianhua
Department of Hepatic Surgery I (Ward I), Shanghai Eastern Hepatobiliary Surgery Hospital, Navy Medical University, Shanghai, China.
Department of Epidemiology, Faculty of Navy Medicine, Navy Medical University, Shanghai, China.
Front Oncol. 2023 Sep 8;13:1249198. doi: 10.3389/fonc.2023.1249198. eCollection 2023.
Hepatocellular carcinoma (HCC) is an extremely malignant tumor that affects individuals throughout the world. One of the main causes of HCC is hepatitis B virus (HBV). Therefore, it is crucial to understand the mechanisms underlying HBV carcinogenesis. Increasing evidence suggests that the HBV X protein (HBx), which is encoded by HBV, plays a significant role in cell apoptosis, DNA damage repair, and cell cycle regulation. This ultimately leads to the development of HCC. Additionally, recent studies have shown that non-coding RNA (ncRNA) also contributes to the carcinogenesis and pathogenesis of different of tumors. ncRNA plays a significant role in the formation of HCC by regulating the inflammatory signaling pathway, activating immune cells, and modifying epigenetics. However, it remains unclear whether ncRNA is involved in the regulation of the carcinogenic mechanisms of HBx. This article reviews the carcinogenic mechanism of HBx and its interaction with ncRNA, providing a novel strategy for the clinical diagnosis and treatment of HCC.
肝细胞癌（HCC）是一种极具恶性的肿瘤，影响着世界各地的人群。HCC的主要病因之一是乙型肝炎病毒（HBV）。因此，了解HBV致癌的潜在机制至关重要。越来越多的证据表明，由HBV编码的HBV X蛋白（HBx）在细胞凋亡、DNA损伤修复和细胞周期调控中发挥着重要作用。这最终导致了HCC的发生。此外，最近的研究表明，非编码RNA（ncRNA）也参与了不同肿瘤的致癌作用和发病机制。ncRNA通过调节炎症信号通路、激活免疫细胞和修饰表观遗传学，在HCC的形成中发挥重要作用。然而，ncRNA是否参与HBx致癌机制的调控仍不清楚。本文综述了HBx的致癌机制及其与ncRNA的相互作用，为HCC的临床诊断和治疗提供了新的策略。
