Dix J H, Levy W J, Fuenning C
Pediatr Dermatol. 1986 Sep;3(4):323-6. doi: 10.1111/j.1525-1470.1986.tb00533.x.
Hypothyroidism is not commonly associated with acanthosis nigricans (AN). We examined a 13-year-old girl with AN, hypertrichosis, and Hashimoto's thyroiditis. Overt biochemical hypothyroidism, thyroid enlargement, and positive titers of antimicrosomal and antithyroglobulin antibodies confirmed Hashimoto's thyroiditis. Both AN and hypertrichosis resolved with thyroid hormone replacement. There was no evidence of insulin resistance, polycystic ovarian disease, lipoatrophy, or other endocrine dysfunction, or of malignancy. In two patients from the literature with AN and hypothyroidism, AN was attributed to associated thyroid carcinoma or insulin resistance, rather than coexisting hypothyroidism. Since the skin lesions improved with thyroid hormone therapy in those two patients and in ours, hypothyroidism appears to be directly involved in the pathogenesis of AN.
甲状腺功能减退症通常与黑棘皮病（AN）无关。我们检查了一名患有AN、多毛症和桥本甲状腺炎的13岁女孩。明显的生化性甲状腺功能减退、甲状腺肿大以及抗微粒体和抗甲状腺球蛋白抗体滴度阳性证实了桥本甲状腺炎。给予甲状腺激素替代治疗后，AN和多毛症均得到缓解。没有胰岛素抵抗、多囊卵巢疾病、脂肪萎缩或其他内分泌功能障碍或恶性肿瘤的证据。在文献报道的另外两名患有AN和甲状腺功能减退症的患者中，AN被归因于相关的甲状腺癌或胰岛素抵抗，而非并存的甲状腺功能减退症。由于在这两名患者以及我们的患者中，皮肤病变均随甲状腺激素治疗而改善，甲状腺功能减退症似乎直接参与了AN的发病机制。
