Nanbu County People's Hospital, Nanchong City, Sichuan Province 637300, China.
Department of Dermatology, Fourth Medical Center of Chinese PLA General Hospital, 51 Fucheng Road, Haidian District, Beijing 100048, China.
J Burn Care Res. 2023 Nov 2;44(6):1327-1333. doi: 10.1093/jbcr/irad146.
Light is an efficient technique that has a significant influence on contemporary medicine. Photodynamic therapy (PDT), which involves the combined action of photosensitizers (PSs), oxygen, and light, has emerged as a therapeutically promising method for treating a broad variety of solid tumors and infectious diseases. Photodynamic therapy is minimally invasive, has few side effects, lightens scars, and reduces tissue loss while preserving organ structure and function. In particular, PDT has a high healing potential for wounds (PDT stimulates wound healing by enhancing re-epithelialization, promoting angiogenesis as well as modulating skin homeostasis). Wound healing involves interactions between many different processes, including coagulation, inflammation, angiogenesis, cellular migration, and proliferation. Poor wound healing with diabetes or extensive burns remains a difficult challenge. This review emphasizes PDT as a potential research field and summarizes PDT's role in wound healing, including normal wounds, chronic wounds, and aging wounds.
光是一种有效的技术，对当代医学有重大影响。光动力疗法（PDT）是一种有治疗前景的方法，涉及光敏剂（PS）、氧气和光的联合作用，可用于治疗多种实体瘤和传染病。光动力疗法具有微创、副作用少、减轻疤痕、减少组织损失的优点，同时保持器官结构和功能。特别是，PDT 对伤口有很高的愈合潜力（PDT 通过促进再上皮化、促进血管生成以及调节皮肤稳态来刺激伤口愈合）。伤口愈合涉及许多不同过程的相互作用，包括凝血、炎症、血管生成、细胞迁移和增殖。糖尿病或大面积烧伤导致的伤口愈合不良仍然是一个难题。本综述强调了 PDT 作为一个潜在的研究领域，并总结了 PDT 在伤口愈合中的作用，包括正常伤口、慢性伤口和老化伤口。
