Oyama Jully, Fernandes Herculano Ramos-Milaré Áquila Carolina, Lopes Lera-Nonose Daniele Stéfanie Sara, Nesi-Reis Vanessa, Galhardo Demarchi Izabel, Alessi Aristides Sandra Mara, Juarez Vieira Teixeira Jorge, Gomes Verzignassi Silveira Thaís, Campana Lonardoni Maria Valdrinez
Graduate Program in Bioscience and Physiopathology, State University of Maringá, Colombo Avenue, 5790, Postal Code 87020-900, Maringá, Paraná, Brazil.
Graduate Program in Health Sciences, State University of Maringá, Colombo Avenue, 5790, Postal Code 87020-900, Maringá, Paraná, Brazil.
Photodiagnosis Photodyn Ther. 2020 Jun;30:101682. doi: 10.1016/j.pdpdt.2020.101682. Epub 2020 Feb 4.
Wounds constitute severe problems in public health. Inappropriate manipulation to promote wound healing and indiscriminate use of antibiotics may contribute to failure in wound treatment, leading to bacterial growth and resistance. Appropriate and correct approaches to wound treatment are crucially important. Further, the development of new and effective treatment modalities is important to decrease infection-related mortality and to reduce patient suffering and side effects. Photodynamic therapy (PDT) could be a promising approach to ameliorate this global health problem. We researched articles that used PDT in wound healing in vivo. The systematic review included articles that investigated the effect of PDT on wound healing in animals, published from May 2008 through 2018, in the databases PubMed and Web of Science. The main types of wounds described in the selected articles were burns, abrasions, and excisional wounds. Most of the studies tested PDT in wounds infected by methicillin-resistant Staphylococcus aureus, S. aureus standard strain, or Pseudomonas aeruginosa. The studies demonstrated that PDT contributes in several ways to the wound healing process, such as killing bacterial cells and stimulating the proliferation of fibroblasts and consequently of collagen and elastin. Based on these studies, PDT provided excellent results for the wound healing process, acting in several steps and accelerating tissue repair. PDT has proven to be a promising therapeutic modality, able to inhibit bacterial regrowth or kill bacteria, contributing significantly to accelerate the wound healing process.
伤口是公共卫生领域的严重问题。促进伤口愈合的不当操作以及抗生素的滥用可能导致伤口治疗失败，进而引发细菌生长和耐药性。采取恰当且正确的伤口治疗方法至关重要。此外，开发新的有效治疗方式对于降低感染相关死亡率、减轻患者痛苦以及减少副作用具有重要意义。光动力疗法（PDT）可能是改善这一全球健康问题的一种有前景的方法。我们检索了在体内伤口愈合中使用PDT的文章。该系统评价纳入了2008年5月至2018年期间发表在PubMed和科学网数据库中研究PDT对动物伤口愈合影响的文章。所选文章中描述的主要伤口类型为烧伤、擦伤和切除伤口。大多数研究在耐甲氧西林金黄色葡萄球菌、金黄色葡萄球菌标准菌株或铜绿假单胞菌感染的伤口中测试了PDT。这些研究表明，PDT在多个方面对伤口愈合过程有促进作用，比如杀死细菌细胞、刺激成纤维细胞增殖，进而促进胶原蛋白和弹性蛋白的生成。基于这些研究，PDT在伤口愈合过程中取得了优异成果，在多个步骤发挥作用并加速组织修复。PDT已被证明是一种有前景的治疗方式，能够抑制细菌再生长或杀死细菌，对加速伤口愈合过程有显著贡献。
