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大麻使用管理兴奋剂的渴望之间的人使用不受管制的药物。

Cannabis use to manage stimulant cravings among people who use unregulated drugs.

机构信息

British Columbia Centre on Substance Use, Vancouver, BC V6Z 2A9, Canada; Department of Medicine, University of British Columbia, Vancouver, BC V6Z 1Y6, Canada.

British Columbia Centre on Substance Use, Vancouver, BC V6Z 2A9, Canada; Department of Medicine, University of British Columbia, Vancouver, BC V6Z 1Y6, Canada.

出版信息

Addict Behav. 2024 Jan;148:107867. doi: 10.1016/j.addbeh.2023.107867. Epub 2023 Sep 22.

Abstract

BACKGROUND

We sought to analyze the association between cannabis use to manage stimulant cravings and self-reported changes in stimulant use among structurally marginalized people who use unregulated drugs (PWUD).

METHODS

The data for this secondary analysis was collected from a cross-sectional questionnaire administered to people who concurrently use cannabis and unregulated stimulants in Vancouver, Canada. We used logistic regression models to analyze the association between cannabis use to manage stimulant cravings and self-reported changes in the frequency of stimulant use.

RESULTS

In total, 297 individuals were included in the present study. Cannabis use to manage stimulant cravings was reported by 134 (45.1 %) participants and 104 (77.6 %) of these participants reported decreasing their stimulant use during periods of cannabis use. In the multivariable logistic regression analysis, cannabis use to manage stimulant cravings (adjusted Odds Ratio [aOR] = 0.24, 95 % confidence interval [CI]: 0.10, 0.56) was significantly associated with self-reported reductions in stimulant use. In the sub-analyses, cannabis use to manage stimulant cravings was significantly associated with reduced stimulant use among people who used crystal methamphetamine daily (aOR = 0.08, 95 % CI: 0.02-0.37) and was not significantly associated with reduced stimulant use among people who used crack/cocaine daily (aOR = 0.33, 95 % CI: 0.04-2.86).

CONCLUSIONS

These findings indicate that cannabis use to manage stimulant cravings is a common harm reduction strategy and suggest that this may be an effective strategy to reduce stimulant use among some PWUD.

摘要

背景

我们旨在分析在结构性边缘化的同时使用未经管制药物的药物使用者(PWUD)中,使用大麻来控制兴奋剂渴求与自我报告的兴奋剂使用变化之间的关联。

方法

本二次分析的数据来自于在加拿大温哥华同时使用大麻和未经管制兴奋剂的人群进行的横断面问卷调查。我们使用逻辑回归模型来分析使用大麻来控制兴奋剂渴求与自我报告的兴奋剂使用频率变化之间的关联。

结果

总共有 297 人纳入本研究。134 人(45.1%)报告使用大麻来控制兴奋剂渴求,其中 104 人(77.6%)报告在使用大麻期间减少了兴奋剂的使用。在多变量逻辑回归分析中,使用大麻来控制兴奋剂渴求(调整后的优势比[aOR] = 0.24,95%置信区间[CI]:0.10,0.56)与自我报告的兴奋剂使用减少显著相关。在亚组分析中,使用大麻来控制兴奋剂渴求与每日使用冰毒者(aOR = 0.08,95%CI:0.02-0.37)减少兴奋剂使用显著相关,而与每日使用快克可卡因者(aOR = 0.33,95%CI:0.04-2.86)减少兴奋剂使用不显著相关。

结论

这些发现表明,使用大麻来控制兴奋剂渴求是一种常见的减少伤害策略,并表明这可能是减少某些 PWUD 兴奋剂使用的有效策略。

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