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推出“快速噬菌体药敏试验”（RPST）：一种可在 8 小时内加速溶菌噬菌体活性试验的常规诊断实验室方法。

Introducing "Rapid phage susceptibility testing" (RPST): an accelerated lytic phage activity test for routine diagnostic laboratories within eight hours.

机构信息

Institute of Medical Microbiology, Virology and Hygiene, University Medicine Rostock, Rostock, Germany.

Institute of Medical Microbiology, Virology and Hygiene, University Medicine Rostock, Rostock, Germany.

出版信息

Diagn Microbiol Infect Dis. 2023 Dec;107(4):116054. doi: 10.1016/j.diagmicrobio.2023.116054. Epub 2023 Sep 3.

DOI:10.1016/j.diagmicrobio.2023.116054
PMID:37748232
Abstract

Phage therapy, particularly for infections due to multi-drug-resistant bacteria, is increasingly gaining in importance. Consecutively, there is a rising need for phage testing in routine diagnostic laboratories. The incubation time of phage susceptibility testing for detecting lytic phage activity on phage/host strain combinations was evaluated. A standardized approach for routine diagnostic laboratories provided reliably detectable lysis zones within 8 hours.

摘要

噬菌体治疗，特别是针对多重耐药菌引起的感染，正变得越来越重要。因此，常规诊断实验室对噬菌体检测的需求也在不断增加。本研究评估了噬菌体敏感性检测的孵育时间，以检测噬菌体/宿主菌株组合上的裂解噬菌体活性。为常规诊断实验室提供的标准化方法可在 8 小时内可靠地检测到裂解区。

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