2nd Pulmonary Medicine Department, Athens Medical School, "Attikon" University Hospital, National and Kapodistrian University of Athens, Athens, Greece; Department of Respiratory Medicine, University General Hospital of Patras, Patras, Greece.
Department of Respiratory Medicine, University General Hospital of Patras, Patras, Greece.
Mult Scler Relat Disord. 2023 Nov;79:105016. doi: 10.1016/j.msard.2023.105016. Epub 2023 Sep 18.
Multiple sclerosis (MS) is a chronic demyelinating inflammatory disorder of the central nervous system that may affect respiratory system at the later stages of the disease. The aim of our study was to evaluate respiratory function and cardiopulmonary exercise testing in ambulatory without aid people with MS (pwMS), and to investigate quality of life parameters and fatigue in this population.
25 pwMS and 16 healthy controls were included in this study. Pulmonary function tests were performed and were followed by proper cardiopulmonary exercise testing with the use of treadmill. Quality of life assessment was done with SF-36 questionnaire.
The mean age of the patient group was 38.4 ± 8.2 years. Spirometric values were within normal limits, and so did lung diffusion capacity, while maximal voluntary ventilation was reduced. In cardiopulmonary exercise testing the patient group showed impairment compared to control group. The statistically significant lower parameters were V'O peak, V'CO peak, RER, V'O/kg peak, V'CO/kg peak, oxygen pulse peak and V'E/V'CO slope. Moreover, there was a negative and statistically significant correlation between CPET values and BMI and MFIS, while there was a positive and statistically significant correlation with quality of life, evaluated by SF-36.
Our study showed that the main cardiopulmonary exercise testing parameters were affected in ambulatory pwMS, even without evidence of respiratory symptoms. Therefore, these people should be evaluated for pulmonary function compromise.
多发性硬化症（MS）是一种中枢神经系统的慢性脱髓鞘炎症性疾病，可能在疾病的后期影响呼吸系统。我们的研究目的是评估无辅助步行多发性硬化症患者（pwMS）的呼吸功能和心肺运动测试，并研究该人群的生活质量参数和疲劳情况。
本研究纳入了 25 名 pwMS 患者和 16 名健康对照者。进行了肺功能检查，随后使用跑步机进行了适当的心肺运动测试。使用 SF-36 问卷进行生活质量评估。
患者组的平均年龄为 38.4±8.2 岁。肺活量计值在正常范围内，肺扩散能力也是如此，而最大自主通气量降低。在心肺运动测试中，与对照组相比，患者组表现出了损伤。具有统计学意义的参数降低有：V'O 峰值、V'CO 峰值、RER、V'O/kg 峰值、V'CO/kg 峰值、氧脉冲峰值和 V'E/V'CO 斜率。此外，CPET 值与 BMI 和 MFIS 呈负相关且具有统计学意义，而与 SF-36 评估的生活质量呈正相关且具有统计学意义。
我们的研究表明，即使没有呼吸症状的证据，无辅助步行的 pwMS 患者的主要心肺运动测试参数也受到了影响。因此，这些人应该评估其肺功能受损情况。
