给予阿扑吗啡的正常大鼠的姿势不对称和侧向旋转

Postural asymmetry and lateralized rotation in normal rats administered apomorphine.

作者信息

Szechtman H, Pisa M

出版信息

Pharmacol Biochem Behav. 1986 Sep;25(3):689-91. doi: 10.1016/0091-3057(86)90160-7.

Abstract

The study examines the hypothesis that the direction of circling exhibited by normal rats administered apomorphine reflects a drug-induced bias to use one specific hindleg for stepping and the other one for postural support. Results indicate that a majority of rats injected with this dopamine receptor agonist do show an asymmetry in the usage of the hindlegs (postural bias). However, the side of more frequent steppings does not predict the direction of circling. Moreover, postural bias may exist without lateralized circling. It is suggested that lateralized circling and postural asymmetry are two of several biases induced by apomorphine that may coexist in individual rats.

摘要

该研究检验了这样一个假设，即给予阿扑吗啡的正常大鼠所表现出的转圈方向反映了药物诱导的偏向，即使用一条特定的后肢进行迈步，而另一条后肢用于姿势支撑。结果表明，大多数注射这种多巴胺受体激动剂的大鼠在后肢使用上确实表现出不对称（姿势偏向）。然而，更频繁迈步的一侧并不能预测转圈的方向。此外，姿势偏向可能在没有侧向转圈的情况下存在。有人提出，侧向转圈和姿势不对称是阿扑吗啡诱导的几种偏向中的两种，它们可能在个体大鼠中共存。