Pharmacological control of the in vivo passive anaphylactic shock by the PAF-acether antagonist compound BN 52021.
作者信息
Vilain B, Lagente V, Touvay C, Desquand S, Randon J, Lefort J, Braquet P, Vargaftig B B
出版信息
Pharmacol Res Commun. 1986 Aug;18 Suppl:119-26. doi: 10.1016/0031-6989(86)90044-5.
PMID:3774840
Abstract
BN 52021 antagonized PAF-acether-induced bronchoconstriction (BC) in the guinea-pig and inhibited BC triggered by antigen in passively sensitized animals. The anti-anaphylactic activity was prevented by propranolol and may either result from an additional property of the drug, independent from PAF antagonism or from different PAF-dependent mechanisms with different responsiveness to the various antagonists.
摘要
Zotero 插件