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Pharmacological control of the in vivo passive anaphylactic shock by the PAF-acether antagonist compound BN 52021.

作者信息

Vilain B, Lagente V, Touvay C, Desquand S, Randon J, Lefort J, Braquet P, Vargaftig B B

出版信息

Pharmacol Res Commun. 1986 Aug;18 Suppl:119-26. doi: 10.1016/0031-6989(86)90044-5.

DOI:10.1016/0031-6989(86)90044-5
PMID:3774840
Abstract

BN 52021 antagonized PAF-acether-induced bronchoconstriction (BC) in the guinea-pig and inhibited BC triggered by antigen in passively sensitized animals. The anti-anaphylactic activity was prevented by propranolol and may either result from an additional property of the drug, independent from PAF antagonism or from different PAF-dependent mechanisms with different responsiveness to the various antagonists.

摘要

相似文献

1
Pharmacological control of the in vivo passive anaphylactic shock by the PAF-acether antagonist compound BN 52021.
Pharmacol Res Commun. 1986 Aug;18 Suppl:119-26. doi: 10.1016/0031-6989(86)90044-5.
2
Interference of the PAF-acether antagonist BN 52021 with passive anaphylaxis in the guinea-pig.血小板活化因子拮抗剂BN 52021对豚鼠被动过敏反应的干扰作用。
Prostaglandins. 1987 Feb;33(2):265-74. doi: 10.1016/0090-6980(87)90011-6.
3
Inhibition of antigen-induced lung anaphylaxis in the guinea-pig by BN 52021 a new specific paf-acether receptor antagonist isolated from Ginkgo biloba.
Agents Actions. 1986 Jan;17(3-4):371-2. doi: 10.1007/BF01982650.
4
A study with BN 52021 demonstrates the involvement of PAF-acether in IgE-dependent anaphylactic bronchoconstriction.一项关于BN 52021的研究表明血小板活化因子（PAF-乙酰醚）参与了IgE依赖性过敏性支气管收缩。
Prostaglandins. 1986 Jul;32(1):121-6. doi: 10.1016/0090-6980(86)90153-x.
5
Protection by two ginkgolides, BN-52020 and BN-52021, against guinea-pig lung anaphylaxis.两种银杏内酯BN - 52020和BN - 52021对豚鼠肺过敏反应的保护作用。
Pharmacol Res Commun. 1986 Sep;18(9):775-93. doi: 10.1016/0031-6989(86)90129-3.
6
Interference of BN 52021 (ginkgolide B) with the bronchopulmonary effects of PAF-acether in the guinea-pig.BN 52021（银杏内酯B）对豚鼠中血小板活化因子乙醚（PAF - 乙醚）支气管肺效应的干扰作用
Eur J Pharmacol. 1986 Aug 7;127(1-2):83-95. doi: 10.1016/0014-2999(86)90208-6.
7
Characterization of platelet activating factor (PAF)-acether-induced contractions of guinea-pig lung strips by selected inhibitors of arachidonic acid metabolism and by PAF-acether antagonists.通过花生四烯酸代谢的特定抑制剂和血小板活化因子（PAF）-乙醚拮抗剂对豚鼠肺条中PAF-乙醚诱导的收缩进行表征。
Immunopharmacology. 1986 Oct;12(2):97-104. doi: 10.1016/0162-3109(86)90035-4.
8
Interference of the PAF-acether antagonist BN 52021 with endotoxin-induced hypotension in the guinea-pig.
Prostaglandins. 1986 Dec;32(6):791-802. doi: 10.1016/0090-6980(86)90090-0.
9
Effect of BN 52021, a specific PAF-acether antagonist, on cardiac anaphylaxis in Langendorff hearts isolated from passively sensitized guinea-pigs.
Eur J Pharmacol. 1986 Oct 14;130(1-2):133-6. doi: 10.1016/0014-2999(86)90192-5.
10
The effects of PAF-acether on the cardiovascular system and their inhibition by a new highly specific PAF-acether receptor antagonist BN 52021.
Pharmacol Res Commun. 1986 Aug;18(8):717-37. doi: 10.1016/0031-6989(86)90114-1.

引用本文的文献

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Platelet-activating factor-mediated NF-kappaB dependency of a late anaphylactic reaction.血小板活化因子介导的迟发型过敏反应对核因子κB的依赖性
J Exp Med. 2003 Jul 7;198(1):145-51. doi: 10.1084/jem.20022129. Epub 2003 Jun 30.
2
Immunoglobulin E-dependent active fatal anaphylaxis in mast cell-deficient mice.肥大细胞缺陷小鼠中免疫球蛋白E依赖性主动致死性过敏反应
J Exp Med. 1998 Nov 2;188(9):1587-92. doi: 10.1084/jem.188.9.1587.
3
Occurrence of disseminated intravascular coagulation (DIC) in active systemic anaphylaxis: role of platelet-activating factor.
全身性过敏反应中弥散性血管内凝血（DIC）的发生：血小板活化因子的作用
Clin Exp Immunol. 1995 Jun;100(3):390-4. doi: 10.1111/j.1365-2249.1995.tb03711.x.
4
Characterization of receptors for platelet-activating factor on platelets, polymorphonuclear leukocytes and macrophages.血小板、多形核白细胞和巨噬细胞上血小板活化因子受体的特性研究。
Br J Pharmacol. 1988 Aug;94(4):1225-33. doi: 10.1111/j.1476-5381.1988.tb11642.x.
5
Interference of BN 52021, an antagonist of PAF, with different forms of active anaphylaxis in the guinea-pig: importance of the booster injection.血小板活化因子拮抗剂BN 52021对豚鼠不同形式主动过敏反应的干扰：加强注射的重要性
Br J Pharmacol. 1991 Mar;102(3):687-95. doi: 10.1111/j.1476-5381.1991.tb12234.x.