Kubis A, Grabowska-Bochenek J
Pharmazie. 1986 Jul;41(7):491-3.
Using methylcellulose with an addition of glycerol or of polyoxyethylene glycol 200 tablets were made which produce after swelling a dressing designed for treatment of Alveolitis sicca dolorosa. The pharmaceutical availability of acetylsalicylic acid and of Nipagine P as well as the swelling degree increase on a parallel line to increasing quantities of hydrophylizators in a tablet. However the washing out time as well as that of half liberation remain in a reversed proportionality to the content of glycerol and of polyoxyethylene glycol 200. The dressings show non ideally plastic viscosity, they possess thixotropic properties and are characterized by a high flow limit. Below the flow limit the dressing possess in properties of on elastic body.
使用甲基纤维素并添加甘油或聚乙二醇 200 制成了片剂,该片剂在溶胀后可制成用于治疗干燥性疼痛性肺泡炎的敷料。乙酰水杨酸和尼泊金 P 的药物可利用度以及溶胀度与片剂中亲水剂数量的增加呈平行上升。然而,洗脱时间以及半释放时间与甘油和聚乙二醇 200 的含量呈反比。这些敷料表现出非理想的塑性粘度,具有触变性,且具有高流动极限。在流动极限以下,敷料具有弹性体的特性。