Grabowska-Bochenek J, Kubis A
Pharmazie. 1986 Sep;41(9):648-50.
Some hydrogel dressings have been investigated to determine their utility for the treatment of painful dry tooth-socket (Alveolitis sicca dolorosa). As drugs mefenamic acid and Nipagin P have been applied. Hydrophilized methylcellulose, 5-15% glycerol or 5-20% PEG 200 were the filling and gel building material. It has been found, that the properties of the dressings depend on the content of the hydrophilizers. The half liberation time of the drugs under study ranges from 0.5 to 11 h, the swelling degree amounts to 366-400%, the washing out time runs to 80-140 min and the period of activity of the dressings inside the tooth-socket amounts to 24-48 h. The dressings show thixotropic properties and a high flow limit.
一些水凝胶敷料已被研究，以确定其在治疗疼痛性干槽症（干性牙槽骨炎）方面的效用。已应用了甲芬那酸和尼泊金P等药物。亲水化甲基纤维素、5 - 15%的甘油或5 - 20%的聚乙二醇200是填充和凝胶构建材料。已发现，敷料的性能取决于亲水剂的含量。所研究药物的半衰期为0.5至11小时，溶胀度为366 - 400%，洗脱时间为80 - 140分钟，敷料在牙槽窝内的活性期为24 - 48小时。这些敷料表现出触变特性和高流动极限。
