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健康参与者嗅觉刺激后瞳孔初始大小变化的心理状态。

Psychological states affecting initial pupil size changes after olfactory stimulation in healthy participants.

机构信息

Department of Otolaryngology, Head and Neck Surgery, Hyogo Prefectural Amagasaki General Medical Center, 2-17-77 Higashinaniwachou, Amagasaki, Hyogo Prefecture, 660-8550, Japan.

出版信息

Sci Rep. 2023 Sep 25;13(1):16050. doi: 10.1038/s41598-023-43004-1.

DOI:10.1038/s41598-023-43004-1
PMID:37749199
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10520065/
Abstract

Odor perception affects physiological and psychological states. Pupillary light reflex (PLR) parameters can be affected by olfactory stimulation and psychological states, although it remains unclear whether the olfactory stimulation-induced psychological changes can associate with PLR parameter changes. This study aimed to investigate effects of olfactory stimulation-induced psychological changes on PLR parameter changes with repeated measurements. We collected data on six mood subscales of the profile of mood states, and on five PLR parameter measurements from 28 healthy participants. Participants underwent a 10-min olfactory stimulation on different days with six odorants available with the T&T olfactometer. As obtained data were clustered, we used linear mixed-effects models for statistical analyses. The olfactory stimulation using the no-odor liquid did not affect mood states and the initial pupil size (INIT). The sweat odorant worsened all mood subscales including fatigue-inertia (Fatigue)/Vigor-Activity (Vigor), and decreased INIT compared to the no-odor liquid. When comparing INIT responses related to changes in mood subscales between the no-odor liquid and the sweat odorant, worsened states of Fatigue/Vigor were associated with decreased INIT in the sweat odorant. Fatigue/Vigor can be used as mental fatigue indicators. Thus, mental fatigue can be associated with decreased INIT in the olfactory stimulation.

摘要

嗅觉感知会影响生理和心理状态。瞳孔光反射 (PLR) 参数可受到嗅觉刺激和心理状态的影响，尽管嗅觉刺激引起的心理变化是否与 PLR 参数变化相关仍不清楚。本研究旨在探讨嗅觉刺激引起的心理变化对 PLR 参数变化的影响，采用重复测量。我们收集了 28 名健康参与者在不同日子的 6 种情绪分量表和 5 种 PLR 参数测量的数据。参与者在不同天使用 T&T 嗅探器接受 10 分钟的嗅觉刺激，有 6 种气味可供选择。由于获得的数据聚类，我们使用线性混合效应模型进行统计分析。使用无气味液体的嗅觉刺激不会影响情绪状态和初始瞳孔大小 (INIT)。与无气味液体相比，汗味会使包括疲劳-惰性 (疲劳)/活力-活动 (活力) 在内的所有情绪分量表恶化，并降低 INIT。当比较无气味液体和汗味之间与情绪分量表变化相关的 INIT 反应时，疲劳/活力恶化与汗味中的 INIT 降低相关。疲劳/活力可用作精神疲劳指标。因此，嗅觉刺激引起的精神疲劳可能与 INIT 降低有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/542c/10520065/7c8151b05c07/41598_2023_43004_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/542c/10520065/28843d60ab02/41598_2023_43004_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/542c/10520065/181ed5231663/41598_2023_43004_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/542c/10520065/7c8151b05c07/41598_2023_43004_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/542c/10520065/28843d60ab02/41598_2023_43004_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/542c/10520065/210283546822/41598_2023_43004_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/542c/10520065/880991c41c85/41598_2023_43004_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/542c/10520065/8c403f1a722f/41598_2023_43004_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/542c/10520065/b6b6c64502d6/41598_2023_43004_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/542c/10520065/181ed5231663/41598_2023_43004_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/542c/10520065/7c8151b05c07/41598_2023_43004_Fig7_HTML.jpg

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本文引用的文献

1
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Int J Psychophysiol. 2023 Mar;185:19-26. doi: 10.1016/j.ijpsycho.2023.01.008. Epub 2023 Jan 17.
2
Decreased initial pupil size and shortened constriction latency due to negative mood states and mental fatigue in clinical subacute pain models.在临床亚急性疼痛模型中，由于负面情绪状态和精神疲劳，初始瞳孔大小减小，收缩潜伏期缩短。
Physiol Behav. 2022 Sep 1;253:113850. doi: 10.1016/j.physbeh.2022.113850. Epub 2022 May 19.
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International consensus statement on allergy and rhinology: Olfaction.
国际过敏与鼻科学学会共识声明：嗅觉。
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