Sun Jifei, Chen Limei, He Jiakai, Du Zhongming, Ma Yue, Wang Zhi, Guo Chunlei, Luo Yi, Gao Deqiang, Hong Yang, Zhang Lei, Xu Fengquan, Cao Jiudong, Hou Xiaobing, Xiao Xue, Tian Jing, Fang Jiliang, Yu Xue
Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Graduate School, China Academy of Chinese Medical Sciences, Beijing, China.
Front Neurosci. 2022 Apr 25;16:876121. doi: 10.3389/fnins.2022.876121. eCollection 2022.
Studies on differences in brain function activity between the first depressive episode (FDE) and recurrent depressive episodes (RDE) are scarce. In this study, we used regional homogeneity (ReHo) and amplitude of low-frequency fluctuations (ALFF) as indices of abnormal brain function activity. We aimed to determine the differences in these indices between patients with FDE and those with RDE, and to investigate the correlation between areas of abnormal brain function and clinical symptoms.
A total of 29 patients with RDE, 28 patients with FDE, and 29 healthy controls (HCs) who underwent resting-state functional magnetic resonance imaging were included in this study. The ReHo and ALFF measurements were used for image analysis and further analysis of the correlation between different brain regions and clinical symptoms.
Analysis of variance showed significant differences among the three groups in ReHo and ALFF in the frontal, parietal, temporal, and occipital lobes. ReHo was higher in the right inferior frontal triangular gyrus and lower in the left inferior temporal gyrus in the RDE group than in the FDE group. Meanwhile, ALFF was higher in the right inferior frontal triangular gyrus, left anterior cingulate gyrus, orbital part of the left middle frontal gyrus, orbital part of the left superior frontal gyrus, and right angular gyrus, but was lower in the right lingual gyrus in the RDE group than in the FDE group. ReHo and ALFF were lower in the left angular gyrus in the RDE and FDE groups than in the HC group. Pearson correlation analysis showed a positive correlation between the ReHo and ALFF values in these abnormal areas in the frontal lobe and the severity of depressive symptoms ( < 0.05). Abnormal areas in the temporal and occipital lobes were negatively correlated with the severity of depressive symptoms ( < 0.05).
The RDE and FDE groups had abnormal neural function activity in some of the same brain regions. ReHo and ALFF were more widely distributed in different brain regions and had more complex neuropathological mechanisms in the RDE group than in the FDE group, especially in the right inferior frontal triangular gyrus of the frontal lobe.
关于首次抑郁发作（FDE）和复发性抑郁发作（RDE）之间脑功能活动差异的研究较少。在本研究中，我们使用局部一致性（ReHo）和低频振幅（ALFF）作为脑功能活动异常的指标。我们旨在确定FDE患者和RDE患者在这些指标上的差异，并研究脑功能异常区域与临床症状之间的相关性。
本研究共纳入29例RDE患者、28例FDE患者和29名健康对照（HCs），他们均接受了静息态功能磁共振成像检查。使用ReHo和ALFF测量进行图像分析，并进一步分析不同脑区与临床症状之间的相关性。
方差分析显示，三组在额叶、顶叶、颞叶和枕叶的ReHo和ALFF存在显著差异。RDE组右侧额下回三角区的ReHo高于FDE组，左侧颞下回的ReHo低于FDE组。同时，RDE组右侧额下回三角区、左侧前扣带回、左侧额中回眶部、左侧额上回眶部和右侧角回的ALFF高于FDE组，但右侧舌回的ALFF低于FDE组。RDE组和FDE组左侧角回的ReHo和ALFF低于HC组。Pearson相关分析显示，额叶这些异常区域的ReHo和ALFF值与抑郁症状严重程度呈正相关（<0.05）。颞叶和枕叶的异常区域与抑郁症状严重程度呈负相关（<0.05）。
RDE组和FDE组在一些相同的脑区存在神经功能活动异常。与FDE组相比，RDE组的ReHo和ALFF在不同脑区分布更广泛，神经病理机制更复杂，尤其是在额叶的右侧额下回三角区。
