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A relationship between DNA helix stability and recognition sites for RNA polymerase.

作者信息

Vollenweider H J, Fiandt M, Szybalski W

出版信息

Science. 1979 Aug 3;205(4405):508-11. doi: 10.1126/science.377494.

DOI:10.1126/science.377494
PMID:377494
Abstract

The RNA polymerase binding sites on the DNA of (i) the aroE-trkA-spc segment of the Escherichia coli genome, (ii) transposon Tn3, (iii) plasmid ColE1, and (iv) coliphage lambda were mapped by electron microscopy, with the use of the BAC technique; these maps were compared with the maps of the early-melting regions for the same genomes. The results indicate that in all these cases the binding sites for the E. coli RNA polymerase lie preferentially in the early melting regions of DNA. These data indicate that helix stability may be an important feature of the multipartite nature of the promoter structure.

摘要

相似文献

1
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2
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Regulation of promoter selection by the bacteriophage T7 RNA polymerase in vitro.噬菌体T7 RNA聚合酶在体外对启动子选择的调控
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