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柴芍胡连汤改善慢性特应性皮炎伴嗜酸性粒细胞增多症：1例报告

Chronic Atopic Dermatitis with Eosinophilia Improved by Daesiho-Tang: A Case Report.

作者信息

Park Min-Cheol, Lee Ju-Hyun, Seong Eun-Jin, Lee Dong-Sung, Jo Eun-Heui

机构信息

Department of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, Wonkwang University Korean Medicine Hospital, Iksan, Jeollabuk-do, 54538, Republic of Korea.

Research Center of Traditional Korean Medicine, Wonkwang University, Iksan, Jeollabuk-do, 54538, Republic of Korea.

出版信息

Clin Cosmet Investig Dermatol. 2023 Sep 20;16:2561-2572. doi: 10.2147/CCID.S424225. eCollection 2023.

DOI:10.2147/CCID.S424225
PMID:37750085
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10518174/
Abstract

PURPOSE

This study is to report a case of chronic atopic dermatitis (AD) with eosinophilia, which did not respond to conventional therapy and was improved by Daesiho-tang (DSHT).

PATIENTS AND METHODS

The patient visited our clinic with symptoms of atopic dermatitis including skin lesions and pruritus. Based on her symptoms, DSHT was prescribed. At each visit, the Scoring Atopic Dermatitis (SCORAD), Dermatology Life Quality Index (DLQI), and accompanying systemic symptoms (ASS) were measured. Multiple Allergen Simultaneous Test (MAST) was initially performed for 108 allergens and analyzed by Western blotting using an Alternate Scoring Method (ASM) according to the specific IgE concentration. Also, peripheral blood laboratory (Lab) tests were performed three times during the patient's visit.

RESULTS

After taking DSHT, the total SCORAD score improved from 62.9 to 23.5, while the patient's ASS also improved. The DLQI score improved from 19 to 5. The total number of eosinophils in the peripheral blood, which showed a mild increase, recovered from 17.2% (0.98 x10/μL) to 4.5% (0.24 x10/μL). The total IgE slightly decreased, while AST and ALT were also restored to normal ranges.

CONCLUSION

Based on this case, DSHT is considered a potential alternative treatment for AD.

摘要

目的

本研究报告一例慢性特应性皮炎（AD）伴嗜酸性粒细胞增多症患者，该患者对传统治疗无反应，但服用大柴胡汤（DSHT）后病情改善。

患者与方法

该患者因特应性皮炎症状（包括皮肤损害和瘙痒）前来我院就诊。根据其症状，开具了大柴胡汤。每次就诊时，测量特应性皮炎评分（SCORAD）、皮肤病生活质量指数（DLQI）以及伴随的全身症状（ASS）。最初对108种变应原进行了多种变应原同步试验（MAST），并根据特异性IgE浓度，采用替代评分法（ASM）通过蛋白质免疫印迹法进行分析。此外，在患者就诊期间进行了三次外周血实验室检查。

结果

服用大柴胡汤后，SCORAD总分从62.9降至23.5，患者的ASS也有所改善。DLQI评分从19降至5。外周血嗜酸性粒细胞总数略有增加，从17.2%（0.98×10⁹/μL）恢复至4.5%（0.24×10⁹/μL）。总IgE略有下降，同时AST和ALT也恢复到正常范围。

结论

基于该病例，大柴胡汤被认为是治疗特应性皮炎的一种潜在替代疗法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/861a/10518174/95395a323bbd/CCID-16-2561-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/861a/10518174/8e7222194ff4/CCID-16-2561-g0001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/861a/10518174/a505eb6efa05/CCID-16-2561-g0003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/861a/10518174/95395a323bbd/CCID-16-2561-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/861a/10518174/8e7222194ff4/CCID-16-2561-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/861a/10518174/5ec5e97e1763/CCID-16-2561-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/861a/10518174/a505eb6efa05/CCID-16-2561-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/861a/10518174/f80c98ca5147/CCID-16-2561-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/861a/10518174/be36ef41917e/CCID-16-2561-g0005.jpg
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