• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

益生菌在成人特应性皮炎治疗中的作用：一项随机对照试验的荟萃分析。

The role of probiotics in the treatment of adult atopic dermatitis: a meta-analysis of randomized controlled trials.

机构信息

Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.

Department of Dermatology and Venerology, Faculty of Medicine, Universitas Airlangga - Dr Soetomo General Academic Hospital, Moestopo Number 47, Surabaya, East Java, Indonesia.

出版信息

J Health Popul Nutr. 2022 Aug 17;41(1):37. doi: 10.1186/s41043-022-00318-6.

DOI:10.1186/s41043-022-00318-6
PMID:35978397
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9386980/
Abstract

BACKGROUND

Atopic dermatitis (AD) is chronic inflammatory skin disease that is relapsing and a serious condition that disrupts the quality of life of affected individuals. Probiotics are an immunomodulator that can enhance the immune control of atopic dermatitis.

METHODS

All randomized controlled trials of probiotics for the treatment of adult AD published before December 2020 were included in this study from the PubMed databases and manual searching.

RESULTS

Six randomized controlled trials (n = 241) were selected for this meta-analysis study. Probiotics were effective in treating adult patients with AD, indicated by the decrease in Scoring Atopic Dermatitis/SCORAD (Mean Difference (MD)  - 7.90, 95% CI - 7.25 to - 6.92; p < 0.00001; I = 96%) and improved quality of life (MD - 7.68, 95% CI - 14.08 to - 1.29; p = 0.02; I = 47%) which were statistically significant. However, skin severity, itch severity, Dermatology Life Quality Index (DLQI), IL-4, TFN-γ, and IgE showed no significant difference in this meta-analysis study (p > 0.05).

LIMITATIONS

The study found no available data for side effects of probiotics.

STRENGTH

This meta-analysis analyzed a total of 241 AD patients of Asian and European origin.

CONCLUSION

The use of probiotics decreased SCORAD significantly in adult patients with AD. Probiotics can improve the quality of life of patients with AD. The use of probiotics in atopic dermatitis has been widely studied, with controversial results. This meta-analysis suggests that the use of probiotics can improve SCORAD and the quality of life of patients with atopic dermatitis.

摘要

背景

特应性皮炎（AD）是一种慢性炎症性皮肤病，具有复发性，会严重影响患者的生活质量。益生菌是一种免疫调节剂，可以增强特应性皮炎的免疫控制。

方法

从 PubMed 数据库和手动搜索中纳入了截至 2020 年 12 月所有关于益生菌治疗成人 AD 的随机对照试验。

结果

本荟萃分析研究共纳入了 6 项随机对照试验（n=241）。益生菌治疗成人 AD 有效，表现为 SCORAD 评分降低（平均差（MD）-7.90，95%置信区间（CI）-7.25 至-6.92；p<0.00001；I²=96%）和生活质量改善（MD-7.68，95%CI-14.08 至-1.29；p=0.02；I²=47%），差异均有统计学意义。然而，皮肤严重程度、瘙痒严重程度、皮肤病生活质量指数（DLQI）、IL-4、TFN-γ 和 IgE 在本荟萃分析中无显著差异（p>0.05）。

局限性

本研究未发现益生菌不良反应的可用数据。

优势

本荟萃分析分析了来自亚洲和欧洲的 241 名 AD 患者。

结论

益生菌可显著降低 AD 成人患者的 SCORAD。益生菌可改善 AD 患者的生活质量。益生菌在特应性皮炎中的应用已广泛研究，但结果存在争议。本荟萃分析表明，益生菌的使用可以改善特应性皮炎患者的 SCORAD 和生活质量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6323/9386980/4e93fbb05444/41043_2022_318_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6323/9386980/0587bb968ead/41043_2022_318_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6323/9386980/63ba3a4170a3/41043_2022_318_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6323/9386980/d97017ecd492/41043_2022_318_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6323/9386980/7e92292ab008/41043_2022_318_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6323/9386980/2278118c54c6/41043_2022_318_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6323/9386980/6c925a2a4d0f/41043_2022_318_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6323/9386980/06f001e1c383/41043_2022_318_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6323/9386980/4e93fbb05444/41043_2022_318_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6323/9386980/0587bb968ead/41043_2022_318_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6323/9386980/63ba3a4170a3/41043_2022_318_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6323/9386980/d97017ecd492/41043_2022_318_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6323/9386980/7e92292ab008/41043_2022_318_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6323/9386980/2278118c54c6/41043_2022_318_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6323/9386980/6c925a2a4d0f/41043_2022_318_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6323/9386980/06f001e1c383/41043_2022_318_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6323/9386980/4e93fbb05444/41043_2022_318_Fig8_HTML.jpg

相似文献

1
The role of probiotics in the treatment of adult atopic dermatitis: a meta-analysis of randomized controlled trials.益生菌在成人特应性皮炎治疗中的作用：一项随机对照试验的荟萃分析。
J Health Popul Nutr. 2022 Aug 17;41(1):37. doi: 10.1186/s41043-022-00318-6.
2
Probiotics for the treatment or prevention of atopic dermatitis: a review of the evidence from randomized controlled trials.用于治疗或预防特应性皮炎的益生菌：来自随机对照试验的证据综述
Am J Clin Dermatol. 2008;9(2):93-103. doi: 10.2165/00128071-200809020-00002.
3
Probiotics for the Treatment of Atopic Dermatitis in Children: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.益生菌治疗儿童特应性皮炎的系统评价和随机对照试验的荟萃分析。
Front Cell Infect Microbiol. 2017 Sep 6;7:392. doi: 10.3389/fcimb.2017.00392. eCollection 2017.
4
Children with atopic dermatitis show clinical improvement after Lactobacillus exposure.患有特应性皮炎的儿童在接触乳酸杆菌后临床症状有所改善。
Clin Exp Allergy. 2015 Apr;45(4):779-87. doi: 10.1111/cea.12489.
5
Effects of probiotics for the treatment of atopic dermatitis: a meta-analysis of randomized controlled trials.益生菌治疗特应性皮炎的疗效：一项随机对照试验的荟萃分析。
Ann Allergy Asthma Immunol. 2014 Aug;113(2):217-26. doi: 10.1016/j.anai.2014.05.021. Epub 2014 Jun 20.
6
The Role of Probiotics in the Prevention and Treatment of Atopic Dermatitis in Children: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials.益生菌在儿童特应性皮炎预防和治疗中的作用：一项随机对照试验的更新系统评价和荟萃分析。
Paediatr Drugs. 2020 Oct;22(5):535-549. doi: 10.1007/s40272-020-00410-6.
7
Effects of Lactobacillus salivarius LS01 (DSM 22775) treatment on adult atopic dermatitis: a randomized placebo-controlled study.唾液乳杆菌 LS01（DSM 22775）治疗成人特应性皮炎的随机安慰剂对照研究。
Int J Immunopathol Pharmacol. 2011 Oct-Dec;24(4):1037-48. doi: 10.1177/039463201102400421.
8
Evaluation of efficacy and safety of Lactobacillus rhamnosus in children aged 4-48 months with atopic dermatitis: An 8-week, double-blind, randomized, placebo-controlled study.评价罗伊氏乳杆菌在 4-48 月龄特应性皮炎儿童中的疗效和安全性：一项为期 8 周、双盲、随机、安慰剂对照研究。
J Microbiol Immunol Infect. 2017 Oct;50(5):684-692. doi: 10.1016/j.jmii.2015.10.003. Epub 2015 Nov 27.
9
Efficacy of probiotics in the treatment of pediatric atopic dermatitis: a meta-analysis of randomized controlled trials.益生菌治疗小儿特应性皮炎的疗效：随机对照试验的荟萃分析。
Ann Allergy Asthma Immunol. 2008 Nov;101(5):508-16. doi: 10.1016/S1081-1206(10)60290-6.
10
Synbiotics for Prevention and Treatment of Atopic Dermatitis: A Meta-analysis of Randomized Clinical Trials.共生元预防和治疗特应性皮炎的效果：一项随机临床试验的荟萃分析。
JAMA Pediatr. 2016 Mar;170(3):236-42. doi: 10.1001/jamapediatrics.2015.3943.

引用本文的文献

1
Anti-Inflammatory Therapies for Atopic Dermatitis: A New Era in Targeted Treatment.特应性皮炎的抗炎疗法：靶向治疗的新时代。
J Clin Med. 2025 Jul 16;14(14):5053. doi: 10.3390/jcm14145053.
2
A refined comparative mouse model of acute and chronic atopic dermatitis.一种改良的急性和慢性特应性皮炎小鼠比较模型。
J Anim Sci Technol. 2025 May;67(3):636-650. doi: 10.5187/jast.2024.e93. Epub 2025 May 31.
3
Therapeutic Potential of Probiotics: A Review of Their Role in Modulating Inflammation.益生菌的治疗潜力：对其在调节炎症中作用的综述

本文引用的文献

1
Beneficial effect of IS-10506 supplementation in adults with atopic dermatitis: a randomized controlled trial.IS-10506 补充剂对特应性皮炎成人的有益作用：一项随机对照试验。
J Dermatolog Treat. 2022 May;33(3):1491-1498. doi: 10.1080/09546634.2020.1836310. Epub 2020 Nov 8.
2
The role of topical probiotics in skin conditions: A systematic review of animal and human studies and implications for future therapies.局部益生菌在皮肤疾病中的作用：动物和人体研究的系统评价及对未来治疗的启示。
Exp Dermatol. 2020 Jan;29(1):15-21. doi: 10.1111/exd.14032. Epub 2019 Sep 18.
3
Changing our microbiome: probiotics in dermatology.
Probiotics Antimicrob Proteins. 2025 Jun 4. doi: 10.1007/s12602-025-10609-z.
4
Influence of Probiotic Administration in Canine Feed: A Comprehensive Review.犬粮中添加益生菌的影响：综述
Vet Sci. 2025 May 7;12(5):449. doi: 10.3390/vetsci12050449.
5
Probiotic Administration Contributes to the Improvement in Intestinal Dysregulation Induced by Allergic Contact Dermatitis.给予益生菌有助于改善过敏性接触性皮炎诱导的肠道失调。
Microorganisms. 2025 May 7;13(5):1082. doi: 10.3390/microorganisms13051082.
6
Progress in Probiotic Science: Prospects of Functional Probiotic-Based Foods and Beverages.益生菌科学进展：基于功能性益生菌的食品和饮料前景
Int J Food Sci. 2025 Apr 14;2025:5567567. doi: 10.1155/ijfo/5567567. eCollection 2025.
7
A Comparative, Multicenter, Prospective, Randomized Study to Evaluate the Efficacy, Safety, and Delay of Relapse of Ceramide-Based Post-biotic Moisturizer Versus Paraffin-Based Moisturizer in Mild to Moderate Atopic Dermatitis.一项比较性、多中心、前瞻性、随机研究，旨在评估基于神经酰胺的后生元保湿剂与基于石蜡的保湿剂在轻度至中度特应性皮炎中的疗效、安全性及复发延迟情况。
Cureus. 2025 Jan 1;17(1):e76762. doi: 10.7759/cureus.76762. eCollection 2025 Jan.
8
Resolution of Chronic Inflammation, Restoration of Epigenetic Disturbances and Correction of Dysbiosis as an Adjunctive Approach to the Treatment of Atopic Dermatitis.慢性炎症的消退、表观遗传紊乱的恢复和微生态失调的纠正作为特应性皮炎治疗的辅助方法。
Cells. 2024 Nov 18;13(22):1899. doi: 10.3390/cells13221899.
9
The Enhancement of Regulatory T Cell Maturation and Th1/Th2 Balance through FOXP3 Expression by in an Ovalbumin-Induced Allergic Skin Animal Model.在卵清蛋白诱导的过敏性皮肤动物模型中，通过FOXP3表达增强调节性T细胞成熟及Th1/Th2平衡
Curr Issues Mol Biol. 2024 Sep 24;46(10):10714-10730. doi: 10.3390/cimb46100636.
10
Topical Probiotics Reduce Atopic Dermatitis Severity: A Systematic Review and Meta-Analysis of Double-Blind, Randomized, Placebo-Controlled Trials.局部用益生菌可减轻特应性皮炎的严重程度：双盲、随机、安慰剂对照试验的系统评价和荟萃分析
Cureus. 2024 Sep 23;16(9):e70001. doi: 10.7759/cureus.70001. eCollection 2024 Sep.
改变我们的微生物群：皮肤科中的益生菌
Br J Dermatol. 2020 Jan;182(1):39-46. doi: 10.1111/bjd.18088. Epub 2019 Jul 28.
4
Atopic dermatitis yardstick: Practical recommendations for an evolving therapeutic landscape.特应性皮炎评估工具：不断发展的治疗领域的实用建议。
Ann Allergy Asthma Immunol. 2018 Jan;120(1):10-22.e2. doi: 10.1016/j.anai.2017.10.039.
5
Effect of Oral Administration of a Mixture of Probiotic Strains on SCORAD Index and Use of Topical Steroids in Young Patients With Moderate Atopic Dermatitis: A Randomized Clinical Trial.口服益生菌混合菌株对中重度特应性皮炎患儿 SCORAD 指数和局部皮质类固醇使用的影响：一项随机临床试验。
JAMA Dermatol. 2018 Jan 1;154(1):37-43. doi: 10.1001/jamadermatol.2017.3647.
6
Lactobacillus plantarum IS-10506 supplementation reduced SCORAD in children with atopic dermatitis.植物乳杆菌 IS-10506 补充剂可降低特应性皮炎儿童的 SCORAD 评分。
Benef Microbes. 2017 Oct 13;8(5):833-840. doi: 10.3920/BM2017.0011. Epub 2017 Oct 12.
7
Effect of atopic dermatitis on quality of life and its psychosocial impact in Asian adolescents.特应性皮炎对亚洲青少年生活质量的影响及其社会心理影响
Australas J Dermatol. 2018 May;59(2):e114-e117. doi: 10.1111/ajd.12632. Epub 2017 Aug 24.
8
Probiotics and Atopic Dermatitis: An Overview.益生菌与特应性皮炎：综述
Front Microbiol. 2016 Apr 12;7:507. doi: 10.3389/fmicb.2016.00507. eCollection 2016.
9
Beneficial effects of citrus juice fermented with Lactobacillus plantarum YIT 0132 on atopic dermatitis: results of daily intake by adult patients in two open trials.植物乳杆菌 YIT 0132 发酵柑橘汁对特应性皮炎的有益作用：两项开放性试验中成年患者每日摄入的结果。
Biosci Microbiota Food Health. 2016;35(1):29-39. doi: 10.12938/bmfh.2015-010. Epub 2015 Oct 27.
10
Quality of Life in Patients with Atopic Dermatitis: Disease Burden, Measurement, and Treatment Benefit.特应性皮炎患者的生活质量：疾病负担、评估及治疗获益。
Am J Clin Dermatol. 2016 Apr;17(2):163-9. doi: 10.1007/s40257-015-0171-3.