Department of Internal Medicine, School of Medicine, Daegu Catholic University Medical Center, Daegu, Republic of Korea.
Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea.
Sci Rep. 2023 Sep 26;13(1):16069. doi: 10.1038/s41598-023-42963-9.
Nonalcoholic fatty liver disease (NAFLD) can lead to a prothrombotic state, which significantly burdens public healthcare systems. This study investigated the relationship between NAFLD and the incidence of venous thromboembolism (VTE) in Korea using National Health Insurance Service-National Sample Cohort 2.0 data. A population-based retrospective cohort analysis was conducted on 472,212 healthy individuals who underwent national health check-ups in Korea from 2009 to 2014. NAFLD was defined using the fatty liver index (FLI). Multivariate Cox proportional hazards regression models were used to analyze the association between FLI and VTE. Individuals were categorized into four quartiles according to FLI values (first quartile [Q1], 0-5.7; second quartile [Q2], 5.8-15.3; third quartile [Q3], 15.4-37.2; and fourth quartile [Q4], > 37.2). The incidence of VTE tended to increase with increasing FLI values (Q1, 598 [0.5%]; Q2, 1,033 [0.9%]; Q3, 1,443 [1.2%]; and Q4, 1,425 [1.2%]). In the age- and sex-adjusted multivariate model, the hazard ratio (HR) (95% confidence interval [CI]) was 1.47 (1.33‒1.62) for Q4 compared with Q1. After adjusting for clinical variables with P < 0.1 in the univariate analyses, the HR (95% CI) was 1.45 (1.30‒1.62) for Q4 compared with Q1. FLI was related to VTE risk, as confirmed after adjusting for other risk factors.
非酒精性脂肪性肝病 (NAFLD) 可导致血栓前状态，显著加重公共医疗保健系统的负担。本研究利用韩国国民健康保险服务-国家样本队列 2.0 数据，调查了 NAFLD 与静脉血栓栓塞症 (VTE) 发病率之间的关系。对 2009 年至 2014 年间在韩国接受国家健康检查的 472212 名健康个体进行了基于人群的回顾性队列分析。使用脂肪性肝病指数 (FLI) 定义 NAFLD。使用多变量 Cox 比例风险回归模型分析 FLI 与 VTE 之间的关联。根据 FLI 值将个体分为四个四分位区间 (第一四分位区间 [Q1]，0-5.7；第二四分位区间 [Q2]，5.8-15.3；第三四分位区间 [Q3]，15.4-37.2；第四四分位区间 [Q4]，>37.2)。VTE 的发病率随着 FLI 值的升高而升高 (Q1，598 [0.5%]；Q2，1033 [0.9%]；Q3，1443 [1.2%]；Q4，1425 [1.2%])。在年龄和性别调整后的多变量模型中，与 Q1 相比，Q4 的危险比 (HR) (95%置信区间 [CI]) 为 1.47 (1.33-1.62)。在单变量分析中 P<0.1 的临床变量进行调整后，与 Q1 相比，Q4 的 HR (95%CI) 为 1.45 (1.30-1.62)。FLI 与 VTE 风险相关，在调整其他危险因素后得到证实。
