Lucija Virović-Jukić, Department of Gastroenterology and Hepatology, Sestre Milosrdnice University Hospital Center, Vinogradska cesta 29, 10000 Zagreb, Croatia,
Croat Med J. 2021 Feb 28;62(1):25-33. doi: 10.3325/cmj.2021.62.25.
Non-alcoholic fatty liver disease (NAFLD) is associated with a number of extrahepatic comorbidities and considerable cardiovascular morbidity and mortality, which is possibly related to coagulation changes associated with metabolic syndrome. Coagulation disorders are common in patients with liver disease of any etiology, and here we review possible alterations in coagulation cascade specific to NAFLD. We discuss derangements in the coagulation cascade and fibrinolysis, endothelial dysfunction, and platelet abnormalities as possible culprits for altered coagulation and explore the significance of these changes for potential treatment targets.
非酒精性脂肪性肝病（NAFLD）与许多肝外合并症以及相当大的心血管发病率和死亡率相关，这可能与代谢综合征相关的凝血变化有关。凝血障碍在任何病因的肝病患者中都很常见，在此我们综述了非酒精性脂肪性肝病中特定的凝血级联反应的可能改变。我们讨论了凝血级联和纤维蛋白溶解、内皮功能障碍和血小板异常的紊乱，作为凝血改变的可能原因，并探讨了这些变化对潜在治疗靶点的意义。
