产前心理社会压力和新冠病毒感染对婴儿注意力及社会情感发展的影响。
Effects of prenatal psychosocial stress and COVID-19 infection on infant attention and socioemotional development.
作者信息
Werchan Denise M, Hendrix Cassandra L, Hume Amy M, Zhang Margaret, Thomason Moriah E, Brito Natalie H
机构信息
Department of Child & Adolescent Psychiatry, NYU Langone, New York, NY, USA.
Department of Applied Psychology, New York University, New York, NY, USA.
出版信息
Pediatr Res. 2024 Apr;95(5):1279-1287. doi: 10.1038/s41390-023-02807-8. Epub 2023 Sep 27.
BACKGROUND
The COVID-19 pandemic dramatically altered the psychosocial environment of pregnant women and new mothers. In addition, prenatal infection is a known risk factor for altered fetal development. Here we examine joint effects of maternal psychosocial stress and COVID-19 infection during pregnancy on infant attention at 6 months postpartum.
METHOD
One-hundred and sixty-seven pregnant mothers and infants (40% non-White; n = 71 females) were recruited in New York City (n = 50 COVID+, n = 117 COVID-). Infants' attentional processing was assessed at 6 months, and socioemotional function and neurodevelopmental risk were evaluated at 12 months.
RESULTS
Maternal psychosocial stress and COVID-19 infection during pregnancy jointly predicted infant attention at 6 months. In mothers reporting positive COVID-19 infection, higher prenatal psychosocial stress was associated with lower infant attention at 6 months. Exploratory analyses indicated that infant attention in turn predicted socioemotional function and neurodevelopmental risk at 12 months.
CONCLUSIONS
These data suggest that maternal psychosocial stress and COVID-19 infection during pregnancy may have joint effects on infant attention at 6 months. This work adds to a growing literature on the effects of the COVID-19 pandemic on infant development, and may point to maternal psychosocial stress as an important target for intervention.
IMPACT
This study found that elevated maternal psychosocial stress and COVID-19 infection during pregnancy jointly predicted lower infant attention scores at 6 months, which is a known marker of risk for neurodevelopmental disorder. In turn, infant attention predicted socioemotional function and risk for neurodevelopmental disorder at 12 months. These data suggest that maternal psychosocial stress may modulate the effects of gestational infection on neurodevelopment and highlight malleable targets for intervention.
背景
新冠疫情极大地改变了孕妇和新妈妈的心理社会环境。此外，产前感染是已知的影响胎儿发育的风险因素。在此，我们研究孕期母亲心理社会压力和新冠感染对产后6个月婴儿注意力的联合影响。
方法
在纽约市招募了167名孕妇及其婴儿（40%为非白人；n = 71名女性）（n = 50名新冠阳性，n = 117名新冠阴性）。在婴儿6个月时评估其注意力加工情况，并在12个月时评估其社会情感功能和神经发育风险。
结果
孕期母亲心理社会压力和新冠感染共同预测了婴儿6个月时的注意力。在报告新冠感染呈阳性的母亲中，较高的产前心理社会压力与婴儿6个月时较低的注意力相关。探索性分析表明，婴儿的注意力反过来又预测了12个月时的社会情感功能和神经发育风险。
结论
这些数据表明，孕期母亲心理社会压力和新冠感染可能对婴儿6个月时的注意力产生联合影响。这项研究增加了关于新冠疫情对婴儿发育影响的文献，并可能指出母亲心理社会压力是一个重要的干预靶点。
影响
本研究发现，孕期母亲心理社会压力升高和新冠感染共同预测了婴儿6个月时较低的注意力得分，而这是神经发育障碍风险的一个已知指标。反过来，婴儿的注意力预测了12个月时的社会情感功能和神经发育障碍风险。这些数据表明，母亲心理社会压力可能调节孕期感染对神经发育的影响，并突出了可调节的干预靶点。
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