在胃pH条件下胆汁酸与考来烯胺的结合。
Binding of bile acids to cholestyramine at gastric pH conditions.
作者信息
Lindenbaum S, Higuchi T
出版信息
J Pharm Sci. 1975 Nov;64(11):1887-9. doi: 10.1002/jps.2600641133.
PMID:486
Abstract
The binding of bile salts to cholestyramine was studied under varying conditions of pH and added electrolyte. The taurine-conjugated bile salts were strongly absorbed by the anion-exchange resin at low pH and in the presence of chloride anions. Glycocholic acid binding was very weak at low pH but increased strongly with increasing pH. The presence of chloride ions strongly decreased the amount of glycocholate bound by the anion-exchange resin.
摘要
在不同pH值和添加电解质的条件下，研究了胆盐与消胆胺的结合情况。在低pH值和存在氯离子的情况下，牛磺酸结合型胆盐被阴离子交换树脂强烈吸收。在低pH值时，甘氨胆酸的结合非常弱，但随着pH值的升高而强烈增加。氯离子的存在强烈降低了阴离子交换树脂结合的甘氨胆酸盐的量。
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