Department of Earth Sciences, Kunming University of Science and Technology, Kunming, China.
College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Front Immunol. 2023 Sep 11;14:1268188. doi: 10.3389/fimmu.2023.1268188. eCollection 2023.
Regulatory T cells (Treg), as members of CD4+ T cells, have garnered extensive attention in the research of tumor progression. Treg cells have the function of inhibiting the immune effector cells, preventing tissue damage, and suppressing inflammation. Under the stimulation of the tumor inflammatory microenvironment (IM), the reprogramming of Treg cells enhances their suppression of immune responses, ultimately promoting tumor immune escape or tumor progression. Reducing the number of Treg cells in the IM or lowering the activity of Treg cells while preventing their reprogramming, can help promote the body's anti-tumor immune responses. This review introduces a reprogramming mechanism of Treg cells in the IM; and discusses the regulation of Treg cells on tumor progression. The control of Treg cells and the response to Treg inflammatory reprogramming in tumor immunotherapy are analyzed and countermeasures are proposed. This work will provide a foundation for downregulating the immunosuppressive role of Treg in the inflammatory environment in future tumor immunotherapy.
调节性 T 细胞（Treg）作为 CD4+T 细胞的成员，在肿瘤进展的研究中受到广泛关注。Treg 细胞具有抑制免疫效应细胞、防止组织损伤和抑制炎症的功能。在肿瘤炎症微环境（IM）的刺激下，Treg 细胞的重编程增强了其对免疫反应的抑制作用，最终促进了肿瘤免疫逃逸或肿瘤进展。减少 IM 中的 Treg 细胞数量或降低 Treg 细胞的活性，同时防止其重编程，有助于促进机体的抗肿瘤免疫反应。本综述介绍了 Treg 细胞在 IM 中的重编程机制，并讨论了 Treg 细胞对肿瘤进展的调控。分析了 Treg 细胞的调控及对 Treg 炎症重编程的反应，并提出了相应的对策。这一工作将为今后肿瘤免疫治疗中下调炎症环境中 Treg 的免疫抑制作用提供基础。
