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住院COVID-19患者入院时白细胞介素-6与NT-脑钠肽前体之间的非线性关系

Nonlinear Relationship Between Interleukin-6 and NT-proBNP at Admission in Hospitalized COVID-19 Patients.

作者信息

Zhang Meijuan, Jiao Zhanquan

机构信息

Department of Cardiology, Tianjin Institute of Respiratory Diseases, Tianjin Haihe Hospital, Tianjin University, Tianjin, People's Republic of China.

出版信息

Infect Drug Resist. 2023 Sep 21;16:6259-6267. doi: 10.2147/IDR.S426470. eCollection 2023.

DOI:10.2147/IDR.S426470
PMID:37753230
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10519174/
Abstract

PURPOSE

Elevated levels of the inflammatory marker interleukin-6 (IL-6) and cardiac injury marker N-terminal pro-B-type natriuretic peptide (NT-proBNP) have been observed in patients with coronavirus disease 2019 (COVID-19). However, the relationship between IL-6 and NT-proBNP levels remains unclear. Therefore, we investigated the relationship between IL-6 and NT-proBNP levels in patients with COVID-19.

PATIENTS AND METHODS

This was a cross-sectional study. Consecutive patients with COVID-19 were included herein. The independent and dependent target variables were the IL-6 and NT-proBNP levels, respectively, measured at baseline. Univariate and multivariate linear regression analyses and curve fitting were also performed.

RESULTS

The average age of the 121 selected participants was 49.8 ± 15.8 years old, and 48.8% (59/121) were male. The estimated β value between -transformed IL-6 and NT-proBNP was 0.28 (95% confidence interval [CI] 0.12-0.44, = 0.001) in univariate logistic regression analysis and 0.09 (95% CI -0.04-0.21, = 0.176) in the fully adjusted model. This relationship was nonlinear, with a point of 2.7, and the β values (and CIs) for the left (<2.7) and right (≥2.7) sides of the inflection point were -0.06 (95% CI -0.23-0.12,  = 0.534) and 0.77 (95% CI 0.18-1.37,  = 0.016) in the fully adjusted model, respectively.

CONCLUSION

Our results suggest a nonlinear association between IL-6 and NT-proBNP levels. Higher IL-6 levels are associated with NT-proBNP in patients with COVID-19.

摘要

目的

在2019冠状病毒病（COVID-19）患者中观察到炎症标志物白细胞介素-6（IL-6）和心脏损伤标志物N端前脑钠肽（NT-proBNP）水平升高。然而，IL-6与NT-proBNP水平之间的关系仍不清楚。因此，我们研究了COVID-19患者中IL-6与NT-proBNP水平之间的关系。

患者与方法

这是一项横断面研究。本研究纳入了连续的COVID-19患者。独立目标变量和因变量分别是基线时测量的IL-6和NT-proBNP水平。还进行了单变量和多变量线性回归分析以及曲线拟合。

结果

121名入选参与者的平均年龄为49.8±15.8岁，48.8%（59/121）为男性。在单变量逻辑回归分析中，-转化后的IL-6与NT-proBNP之间的估计β值为0.28（95%置信区间[CI]0.12 - 0.

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdb6/10519174/4c4ce31cb512/IDR-16-6259-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdb6/10519174/997f4d88fc27/IDR-16-6259-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdb6/10519174/4c4ce31cb512/IDR-16-6259-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdb6/10519174/997f4d88fc27/IDR-16-6259-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdb6/10519174/4c4ce31cb512/IDR-16-6259-g0002.jpg

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