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Outcome predictors in SARS-CoV-2 disease (COVID-19): The prominent role of IL-6 levels and an IL-6 gene polymorphism in a western Sicilian population.严重急性呼吸综合征冠状病毒2型疾病（COVID-19）的预后预测指标：白细胞介素-6水平和白细胞介素-6基因多态性在西西里岛西部人群中的显著作用
J Infect. 2022 Aug;85(2):174-211. doi: 10.1016/j.jinf.2022.04.043. Epub 2022 Apr 29.
2
Polymorphism in promotor region of IL6 gene as a predictor for severity in COVID -19 patients.IL6 基因启动子区域多态性可预测 COVID-19 患者的病情严重程度。
Egypt J Immunol. 2022 Apr;29(2):1-9.
3
Vitamin D and COVID-19 severity and related mortality: a prospective study in Italy.维生素 D 与 COVID-19 严重程度和相关死亡率：意大利的一项前瞻性研究。
BMC Infect Dis. 2021 Jun 14;21(1):566. doi: 10.1186/s12879-021-06281-7.
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Impact of SARS-CoV-2 on saliva: TNF-⍺, IL-6, IL-10, lactoferrin, lysozyme, IgG, IgA, and IgM.SARS-CoV-2 对唾液的影响：TNF-α、IL-6、IL-10、乳铁蛋白、溶菌酶、IgG、IgA 和 IgM。
J Oral Biosci. 2022 Mar;64(1):108-113. doi: 10.1016/j.job.2022.01.007. Epub 2022 Jan 25.
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IL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individuals.白细胞介素-33 在 COVID-19 恢复期个体中对 SARS-CoV-2 的反应与血清阳性相关。
Nat Commun. 2021 Apr 9;12(1):2133. doi: 10.1038/s41467-021-22449-w.
6
Daily monitoring of viral load measured as SARS-CoV-2 antigen and RNA in blood, IL-6, CRP and complement C3d predicts outcome in patients hospitalized with COVID-19.每日监测病毒载量，通过血液中的 SARS-CoV-2 抗原和 RNA、IL-6、CRP 和补体 C3d 进行测量，可以预测 COVID-19 住院患者的结局。
Clin Chem Lab Med. 2021 Aug 30;59(12):1988-1997. doi: 10.1515/cclm-2021-0694. Print 2021 Nov 25.
7
Reply to: Population genetic considerations regarding the interpretation of within-patient SARS-CoV-2 polymorphism data.回复：关于患者体内严重急性呼吸综合征冠状病毒2（SARS-CoV-2）多态性数据解读的群体遗传学考量
Nat Commun. 2024 Apr 16;15(1):3239. doi: 10.1038/s41467-024-46262-3.
8
COVID-19 related acute necrotizing encephalopathy with extremely high interleukin-6 and RANBP2 mutation in a patient with recently immunized inactivated virus vaccine and no pulmonary involvement.COVID-19 相关急性坏死性脑病伴极高白细胞介素-6 和 RANBP2 突变，患者近期接种过灭活病毒疫苗且无肺部受累。
BMC Infect Dis. 2022 Jul 23;22(1):640. doi: 10.1186/s12879-022-07610-0.
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Toward finding the difference between untreated celiac disease and COVID-19 infected patients in terms of CD4, CD25 (IL-2 Rα), FOXP3 and IL-6 expressions as genes affecting immune homeostasis.为了寻找未经治疗的乳糜泻患者和 COVID-19 感染患者在影响免疫稳态的基因 CD4、CD25（IL-2Rα）、FOXP3 和 IL-6 表达方面的差异。
BMC Gastroenterol. 2021 Dec 11;21(1):462. doi: 10.1186/s12876-021-02056-1.
10
Changes of serum IL-10, IL-1β, IL-6, MCP-1, TNF-α, IP-10 and IL-4 in COVID-19 patients.COVID-19 患者血清中 IL-10、IL-1β、IL-6、MCP-1、TNF-α、IP-10 和 IL-4 的变化。
Int J Clin Pract. 2021 Sep;75(9):e14462. doi: 10.1111/ijcp.14462. Epub 2021 Jul 4.

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Herbal and Dietary Supplements as Adjunctive Treatment for Mild SARS-CoV-2 Infection in Italy.草药和膳食补充剂作为意大利轻度新型冠状病毒感染辅助治疗手段
Nutrients. 2025 Jan 9;17(2):230. doi: 10.3390/nu17020230.
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Genetic variant rs1205 is associated with COVID-19 outcomes: The Strong Heart Study and Strong Heart Family Study.基因变体rs1205与新冠病毒疾病（COVID-19）的预后相关：强心研究和强心家族研究
PLoS One. 2024 Apr 25;19(4):e0302464. doi: 10.1371/journal.pone.0302464. eCollection 2024.
3
Association of IL-10-592 C > A /-1082 A > G and the TNFα -308 G > A with susceptibility to COVID-19 and clinical outcomes.白细胞介素-10-592C > A/-1082A > G 和肿瘤坏死因子-α-308G > A 与 COVID-19 易感性和临床结局的关联。
BMC Med Genomics. 2024 Jan 29;17(1):40. doi: 10.1186/s12920-023-01793-4.
4
Nonlinear Relationship Between Interleukin-6 and NT-proBNP at Admission in Hospitalized COVID-19 Patients.住院COVID-19患者入院时白细胞介素-6与NT-脑钠肽前体之间的非线性关系
Infect Drug Resist. 2023 Sep 21;16:6259-6267. doi: 10.2147/IDR.S426470. eCollection 2023.
5
Biomarkers of immunothrombosis and polymorphisms of IL2, IL6, and IL10 genes as predictors of the severity of COVID-19 in a Kazakh population.免疫血栓形成的生物标志物和 IL2、IL6 和 IL10 基因的多态性作为哈萨克人群 COVID-19 严重程度的预测因子。
PLoS One. 2023 Jun 30;18(6):e0288139. doi: 10.1371/journal.pone.0288139. eCollection 2023.
6
Anemia as a risk factor for disease progression in patients admitted for COVID-19: data from a large, multicenter cohort study.贫血作为 COVID-19 住院患者疾病进展的危险因素：一项大型多中心队列研究的数据。
Sci Rep. 2023 Jun 3;13(1):9035. doi: 10.1038/s41598-023-36208-y.
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Ct, polymorphism, and laboratory biomarkers for predicting chemosensory dysfunctions and mortality in COVID-19.用于预测COVID-19患者化学感觉功能障碍和死亡率的CT、多态性及实验室生物标志物
Future Sci OA. 2023 Mar 9;9(2):FSO838. doi: 10.2144/fsoa-2022-0082. eCollection 2023 Feb.
8
Can Baseline IL-6 Levels Predict Long COVID in Subjects Hospitalized for SARS-CoV-2 Disease?基线白细胞介素 6 水平能否预测因 SARS-CoV-2 疾病住院的患者发生长新冠？
Int J Mol Sci. 2023 Jan 15;24(2):1731. doi: 10.3390/ijms24021731.
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COVID in 2022. Clinical risk management of sars-cov-2 positive patients admitted to an internal medicine ward.2022年的新型冠状病毒肺炎。内科病房收治的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）阳性患者的临床风险管理
Clin Exp Med. 2023 Aug;23(4):1345-1347. doi: 10.1007/s10238-022-00977-z. Epub 2022 Dec 17.
10
Genetic variation of Golgi membrane protein 1 is associated with COVID-19 disease.高尔基体膜蛋白1的基因变异与新冠肺炎疾病相关。
J Infect. 2022 Nov;85(5):e164-e166. doi: 10.1016/j.jinf.2022.07.013. Epub 2022 Jul 22.

本文引用的文献

1
Assessing the potential correlation of polymorphisms in the IL6R with relative IL6 elevation in severely ill COVID-19 patients'.评估 IL6R 多态性与重症 COVID-19 患者相对 IL6 升高的潜在相关性。
Cytokine. 2021 Dec;148:155662. doi: 10.1016/j.cyto.2021.155662. Epub 2021 Jul 29.
2
Cardiac Complications and Pertaining Mortality Rate in COVID-19 Patients; a Systematic Review and Meta-Analysis.COVID-19患者的心脏并发症及相关死亡率；一项系统评价与荟萃分析
Arch Acad Emerg Med. 2021 Feb 13;9(1):e18. doi: 10.22037/aaem.v9i1.1071. eCollection 2021.
3
At the peak of COVID-19 age and disease severity but not comorbidities are predictors of mortality: COVID-19 burden in Bergamo, Italy.在 COVID-19 发病年龄和疾病严重程度高峰期，但不是合并症，是死亡的预测因素：意大利贝加莫的 COVID-19 负担。
Panminerva Med. 2021 Mar;63(1):51-61. doi: 10.23736/S0031-0808.20.04063-X. Epub 2020 Nov 27.
4
Neutrophil/lymphocyte ratio-A marker of COVID-19 pneumonia severity.中性粒细胞/淋巴细胞比值-COVID-19 肺炎严重程度的标志物。
Int J Clin Pract. 2021 Apr;75(4):e13698. doi: 10.1111/ijcp.13698. Epub 2021 Jan 12.
5
Interleukin-6 as prognosticator in patients with COVID-19.白细胞介素-6作为新型冠状病毒肺炎患者的预后指标
J Infect. 2020 Sep;81(3):452-482. doi: 10.1016/j.jinf.2020.06.008. Epub 2020 Jun 8.
6
Elevated interleukin-6 and severe COVID-19: A meta-analysis.白细胞介素-6升高与重症新型冠状病毒肺炎：一项荟萃分析。
J Med Virol. 2020 Nov;92(11):2283-2285. doi: 10.1002/jmv.25948. Epub 2020 Jun 2.
7
Risk factors of critical & mortal COVID-19 cases: A systematic literature review and meta-analysis.危重症和死亡 COVID-19 病例的风险因素：系统文献回顾和荟萃分析。
J Infect. 2020 Aug;81(2):e16-e25. doi: 10.1016/j.jinf.2020.04.021. Epub 2020 Apr 23.
8
A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects.白细胞介素6受体（IL-6r）基因的一种常见变体可提高IL-6r和IL-6水平，且无其他炎症效应。
Genes Immun. 2007 Oct;8(7):552-9. doi: 10.1038/sj.gene.6364414. Epub 2007 Aug 2.

Outcome predictors in SARS-CoV-2 disease (COVID-19): The prominent role of IL-6 levels and an IL-6 gene polymorphism in a western Sicilian population.

作者信息

Giannitrapani Lydia, Augello Giuseppa, Mirarchi Luigi, Amodeo Simona, Veronese Nicola, Sasso Bruna Lo, Giglio Rosaria Vincenza, Licata Anna, Barbagallo Mario, Ciaccio Marcello, Cervello Melchiorre, Soresi Maurizio

机构信息

Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy; Institute for Biomedical Research and Innovation, National Research Council, Via Ugo La Malfa 153, Palermo 90146, Italy.

Institute for Biomedical Research and Innovation, National Research Council, Via Ugo La Malfa 153, Palermo 90146, Italy.

出版信息

J Infect. 2022 Aug;85(2):174-211. doi: 10.1016/j.jinf.2022.04.043. Epub 2022 Apr 29.

DOI:10.1016/j.jinf.2022.04.043
PMID:35490738
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9050196/
Abstract
摘要