Shi Fan, Zhao Mei, Zheng Shudan, Zheng Lihong, Wang Haiqiang
School of Heilongjiang University of Chinese Medicine, Harbin, China.
Department of Internal Medicine, Fourth Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China.
Front Genet. 2023 Sep 11;14:1213916. doi: 10.3389/fgene.2023.1213916. eCollection 2023.
Metabolism-related fatty liver disease (MAFLD) is the most common form of chronic liver disease in the world. Its pathogenesis is influenced by both environmental and genetic factors. With the upgrading of gene screening methods and the development of human genome project, whole genome scanning has been widely used to screen genes related to MAFLD, and more and more genetic variation factors related to MAFLD susceptibility have been discovered. There are genetic variants that are highly correlated with the occurrence and development of MAFLD, and there are genetic variants that are protective of MAFLD. These genetic variants affect the development of MAFLD by influencing lipid metabolism and insulin resistance. Therefore, in-depth analysis of different mechanisms of genetic variation and targeting of specific genetic variation genes may provide a new idea for the early prediction and diagnosis of diseases and individualized precision therapy, which may be a promising strategy for the treatment of MAFLD.
代谢相关脂肪性肝病（MAFLD）是全球最常见的慢性肝病形式。其发病机制受环境和遗传因素的影响。随着基因筛查方法的升级以及人类基因组计划的开展，全基因组扫描已广泛应用于筛查与MAFLD相关的基因，并且越来越多与MAFLD易感性相关的基因变异因素被发现。存在与MAFLD发生发展高度相关的基因变异，也存在对MAFLD有保护作用的基因变异。这些基因变异通过影响脂质代谢和胰岛素抵抗来影响MAFLD的发展。因此，深入分析基因变异的不同机制并针对特定基因变异进行靶向治疗，可能为疾病的早期预测和诊断以及个体化精准治疗提供新思路，这可能是治疗MAFLD的一种有前景的策略。
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