Chi Zhenfei, Teng Yun, Liu Yuting, Gao Lu, Yang Junhan, Zhang Zhe
Liaoning University of Traditional Chinese Medicine, PR China.
Liaoning University of Traditional Chinese Medicine, PR China.
Ann Hepatol. 2023 Sep-Oct;28(5):101125. doi: 10.1016/j.aohep.2023.101125. Epub 2023 Jun 5.
This study aims to explore the association between Klotho and Non-Alcoholic Fatty Liver Disease (NAFLD), a condition affecting millions worldwide. Klotho may have a protective effect against NAFLD mechanisms like inflammation, oxidative stress, and fibrosis. The study will use FLI and FIB-4 score to diagnose NAFLD in a large population for investigating the link between Klotho and NAFLD.
The study aimed to explore the association between Klotho and NAFLD by measuring the α-Klotho protein levels in the participants' blood using ELISA. Patients with underlying chronic liver diseases were excluded. The severity of NAFLD was evaluated using FLI and FIB-4, and logistic regression models were used to analyze the data obtained from NHANES. Subgroup analyses were conducted to study Klotho's effect on hepatic steatosis and fibrosis in diverse subpopulations.
The study found that low levels of α-Klotho were associated with NAFLD, with ORs ranging from 0.72 to 0.83. However, high levels of α-Klotho were associated with NAFLD-related fibrosis. The Q4 group showed significant results in individuals aged 51 years or younger and in females. Non-Hispanic White ethnicity, education level of high school or above, non-smoking, non-hypertension, and non-diabetic groups showed negative correlations.
Our study suggests a potential correlation between α-Klotho levels in the blood and NAFLD in adult patients, especially among younger individuals, females and Non-Hispanic Whites. Elevated α-Klotho levels may have therapeutic benefits in treating NAFLD. Further research is required to validate these findings, but they provide new insights for managing this condition.
本研究旨在探讨klotho与非酒精性脂肪性肝病（NAFLD）之间的关联，NAFLD是一种影响全球数百万人的疾病。Klotho可能对NAFLD的炎症、氧化应激和纤维化等机制具有保护作用。该研究将使用脂肪肝指数（FLI）和FIB-4评分在大量人群中诊断NAFLD，以研究Klotho与NAFLD之间的联系。
该研究旨在通过酶联免疫吸附测定法（ELISA）测量参与者血液中的α-Klotho蛋白水平，以探讨Klotho与NAFLD之间的关联。排除患有潜在慢性肝病的患者。使用FLI和FIB-4评估NAFLD的严重程度，并使用逻辑回归模型分析从美国国家健康与营养检查调查（NHANES）获得的数据。进行亚组分析以研究Klotho在不同亚人群中对肝脂肪变性和纤维化的影响。
研究发现，α-Klotho水平低与NAFLD相关，比值比（OR）范围为0.72至0.83。然而，α-Klotho水平高与NAFLD相关纤维化有关。在51岁及以下个体和女性中，第四四分位数组显示出显著结果。非西班牙裔白人种族、高中及以上教育水平、不吸烟、无高血压和非糖尿病组呈负相关。
我们的研究表明，成年患者血液中的α-Klotho水平与NAFLD之间存在潜在关联，尤其是在年轻个体、女性和非西班牙裔白人中。升高的α-Klotho水平可能对治疗NAFLD具有治疗益处。需要进一步研究来验证这些发现，但它们为管理这种疾病提供了新的见解。
