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人参皂苷 Rg1 通过 Sirt1-Nrf2-BDNF 通路减轻 D-半乳糖诱导的神经干细胞衰老。

Ginsenoside Rg1 attenuates D-galactose-induced neural stem cell senescence via the Sirt1-Nrf2-BDNF pathway.

机构信息

Lab of Stem Cell and Tissue Engineering, Department of Histology and Embryology, Chongqing Medical University, Chongqing, China.

Neuroscience Research Center, College of basic medicine, Chongqing Medical University, Chongqing, China.

出版信息

Eur J Neurosci. 2023 Nov;58(9):4084-4101. doi: 10.1111/ejn.16147. Epub 2023 Sep 27.

DOI:10.1111/ejn.16147
PMID:37753701
Abstract

With the ageing of society's population, neurodegenerative diseases have become an important factor affecting the quality of life and mortality in the elderly. Since its physiopathological processes are complex and the authorized medications have recently been shown to have several adverse effects, the development of safe and efficient medications is urgently needed. In this study, we looked at how ginsenoside Rg1 works to postpone neural stem cell ageing and brain ageing, giving it a solid scientific foundation for use as a therapeutic therapy for neurodegenerative diseases.

摘要

随着社会人口老龄化,神经退行性疾病已成为影响老年人生活质量和死亡率的重要因素。由于其病理生理过程复杂,最近已证明授权药物有多种不良反应,因此迫切需要开发安全有效的药物。在这项研究中,我们研究了人参皂苷 Rg1 如何延缓神经干细胞衰老和大脑衰老,为其作为神经退行性疾病治疗方法提供了坚实的科学基础。

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引用本文的文献

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