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基于 SERS 的用于检测阿尔茨海默病的光学纳米生物传感器。

SERS-Based Optical Nanobiosensors for the Detection of Alzheimer's Disease.

机构信息

Department of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, China.

Center for Neurodegenerative Disease Research, Renmin Hospital of Wuhan University, Wuhan 430060, China.

出版信息

Biosensors (Basel). 2023 Sep 11;13(9):880. doi: 10.3390/bios13090880.

DOI:10.3390/bios13090880
PMID:37754114
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10526933/
Abstract

Alzheimer's disease (AD) is a leading cause of dementia, impacting millions worldwide. However, its complex neuropathologic features and heterogeneous pathophysiology present significant challenges for diagnosis and treatment. To address the urgent need for early AD diagnosis, this review focuses on surface-enhanced Raman scattering (SERS)-based biosensors, leveraging the excellent optical properties of nanomaterials to enhance detection performance. These highly sensitive and noninvasive biosensors offer opportunities for biomarker-driven clinical diagnostics and precision medicine. The review highlights various types of SERS-based biosensors targeting AD biomarkers, discussing their potential applications and contributions to AD diagnosis. Specific details about nanomaterials and targeted AD biomarkers are provided. Furthermore, the future research directions and challenges for improving AD marker detection using SERS sensors are outlined.

摘要

阿尔茨海默病（AD）是痴呆的主要病因，影响着全球数百万人。然而，其复杂的神经病理学特征和异质的病理生理学为诊断和治疗带来了重大挑战。为了满足对 AD 早期诊断的迫切需求，本综述聚焦于基于表面增强拉曼散射（SERS）的生物传感器，利用纳米材料的优异光学特性来增强检测性能。这些高灵敏度和非侵入性的生物传感器为基于生物标志物的临床诊断和精准医疗提供了机会。本综述强调了各种针对 AD 生物标志物的基于 SERS 的生物传感器，讨论了它们在 AD 诊断中的潜在应用和贡献。提供了有关纳米材料和靶向 AD 生物标志物的具体细节。此外，还概述了使用 SERS 传感器改善 AD 标志物检测的未来研究方向和挑战。

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