Watson D C, Reitz B A, Baumgartner W A, Raney A A, Oyer P E, Stinson E B, Shumway N E
Surgery. 1979 Jul;86(1):56-9.
Between January 1, 1977, and September 15, 1978, 39 cardiac transplants were performed on 38 patients. Twenty donor hearts were removed at Stanford University Hospital, and 19 donor hearts were removed at distant hospitals. The characteristics of recipients and donors in both groups were similar. The only significant difference between donor hearts was the mean ischemia time (154 +/- 30 minutes in distant hearts and 52 +/- 12 minutes in local hearts, P less than 0.001). As of February 1, 1979, the total mortality rate was 32% for the distant heart donors and 40% for the local heart donors. No difference between the two groups was present in immediate myocardial function, the need for postoperative inotropic support, the mortality rate within the first 90 days after operation, the mean maximum serum enzyme levels, the occurrence of rejection or infection, and the histological appearance of the hearts, both early and late. The results of cardiac transplantation when hearts are removed at distant hospitals are entirely comparable to the results with hearts removed on site with a minimum ishchemic time. Distant heart procurement provides an expanded donor pool for potential cardiac recipients.
1977年1月1日至1978年9月15日期间，对38例患者进行了39例心脏移植手术。20颗供体心脏在斯坦福大学医院摘取，19颗供体心脏在其他医院摘取。两组受者和供者的特征相似。供体心脏之间唯一显著的差异是平均缺血时间（其他医院心脏为154±30分钟，本地心脏为52±12分钟，P<0.001）。截至1979年2月1日，其他医院心脏供体的总死亡率为32%，本地心脏供体的总死亡率为40%。两组在即刻心肌功能、术后是否需要使用正性肌力药物支持、术后90天内的死亡率、血清酶最高水平均值、排斥反应或感染的发生率以及心脏早期和晚期的组织学表现方面均无差异。从其他医院摘取心脏进行心脏移植的结果与在最短缺血时间下就地摘取心脏的结果完全可比。从其他医院获取心脏可为潜在的心脏受者提供更大的供体库。
