Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Reprod Biol Endocrinol. 2012 Feb 6;10:10. doi: 10.1186/1477-7827-10-10.
Polycystic ovary syndrome (PCOS) is linked to obesity, impaired glucose tolerance and diabetes. Recently, studies have found that preptin enhances insulin secretion in rats and might play a role in the pathogenesis of diabetes and PCOS in humans. The aim of this study was to evaluate the relationship between PCOS, glucose tolerance status, and serum preptin level.
This study was conducted in a university-affiliated hospital from October 2010 to August 2011. Anthropometric parameters, sex hormone concentrations, blood pressure, lipid profiles, fasting glucose and insulin, 2-h blood glucose after glucose overloaded (2hOGTT), glycosylated haemoglobin (HbA1c), homeostasis model assessment-insulin resistance index (HOMA-IR), and serum preptin of the samples were analyzed.
Sixty-three PCOS patients, including 33 women with normal glucose tolerance (NGT) and 30 women with impaired glucose tolerance (IGT), and 63 patients without PCOS, including 35 women with NGT and 28 women with IGT were recruited in this study. For patients with and without PCOS, women with IGT had higher serum preptin levels compared with women with NGT. Preptin levels in PCOS patients were higher compared with patients without PCOS, but the difference was not significant. Fasting serum preptin levels correlated positively with TG, SBP, DBP, FBG, 2hOGTT, and HOMA-IR in simple regression analysis of the pooled data. While in multiple stepwise regression analysis, preptin levels were independently related with glucose tolerance, but not with PCOS.
Irrespective of PCOS status, women with IGT had higher serum preptin levels compared with women with NGT. Preptin levels are related with glucose tolerance status, but not with PCOS status.
多囊卵巢综合征（PCOS）与肥胖、葡萄糖耐量受损和糖尿病有关。最近的研究发现，前白蛋白可增强大鼠胰岛素分泌，可能在人类糖尿病和 PCOS 的发病机制中发挥作用。本研究旨在评估 PCOS、葡萄糖耐量状态和血清前白蛋白水平之间的关系。
本研究于 2010 年 10 月至 2011 年 8 月在一所大学附属医院进行。分析了样本的人体测量参数、性激素浓度、血压、血脂谱、空腹血糖和胰岛素、葡萄糖负荷后 2 小时血糖（2hOGTT）、糖化血红蛋白（HbA1c）、稳态模型评估-胰岛素抵抗指数（HOMA-IR）和血清前白蛋白。
本研究纳入了 63 例 PCOS 患者，包括 33 例糖耐量正常（NGT）的女性和 30 例糖耐量受损（IGT）的女性，以及 63 例无 PCOS 的患者，包括 35 例 NGT 的女性和 28 例 IGT 的女性。对于有和无 PCOS 的患者，IGT 的女性血清前白蛋白水平高于 NGT 的女性。与无 PCOS 的患者相比，PCOS 患者的前白蛋白水平较高，但差异无统计学意义。在对汇总数据进行简单回归分析时，空腹血清前白蛋白水平与 TG、SBP、DBP、FBG、2hOGTT 和 HOMA-IR 呈正相关。而在多元逐步回归分析中，前白蛋白水平与葡萄糖耐量独立相关，而与 PCOS 无关。
无论 PCOS 状态如何，IGT 的女性血清前白蛋白水平均高于 NGT 的女性。前白蛋白水平与葡萄糖耐量状态有关，而与 PCOS 状态无关。
